Sleep-disordered breathing (SDB) is a common disorder with serious health consequences. Obesity is a major cause of SDB, and due to the ongoing obesity epidemic, previous prevalence estimates need updating. This study estimated SDB prevalence in the U.S. for 1988–1994 and 2007–2010 using data from the Wisconsin Sleep Cohort Study, a long-term study of employed adults. The study included 1,520 participants aged 30–70 years who underwent polysomnography to assess SDB. Prevalence was modeled based on age, sex, and BMI, and estimates were extrapolated to U.S. BMI distributions from the National Health and Nutrition Examination Survey (NHANES). The current prevalence of moderate to severe SDB (AHI ≥15) is 10% among 30–49-year-old men, 17% among 50–70-year-old men, 3% among 30–49-year-old women, and 9% among 50–70-year-old women. These rates represent substantial increases over the past two decades, with relative increases ranging from 14% to 55% depending on the subgroup. SDB prevalence has increased significantly, particularly among middle-aged adults. The study highlights the need for updated prevalence estimates to guide clinical and public health interventions. The findings suggest that SDB prevalence has risen substantially, with a growing burden on public health due to the increasing prevalence of obesity. The study also emphasizes the importance of monitoring SDB prevalence to address its serious health consequences, including cardiovascular disease, cognitive decline, mood disorders, and premature death. The study provides updated prevalence estimates for SDB by age, sex, and BMI strata, which can help inform future public health strategies.Sleep-disordered breathing (SDB) is a common disorder with serious health consequences. Obesity is a major cause of SDB, and due to the ongoing obesity epidemic, previous prevalence estimates need updating. This study estimated SDB prevalence in the U.S. for 1988–1994 and 2007–2010 using data from the Wisconsin Sleep Cohort Study, a long-term study of employed adults. The study included 1,520 participants aged 30–70 years who underwent polysomnography to assess SDB. Prevalence was modeled based on age, sex, and BMI, and estimates were extrapolated to U.S. BMI distributions from the National Health and Nutrition Examination Survey (NHANES). The current prevalence of moderate to severe SDB (AHI ≥15) is 10% among 30–49-year-old men, 17% among 50–70-year-old men, 3% among 30–49-year-old women, and 9% among 50–70-year-old women. These rates represent substantial increases over the past two decades, with relative increases ranging from 14% to 55% depending on the subgroup. SDB prevalence has increased significantly, particularly among middle-aged adults. The study highlights the need for updated prevalence estimates to guide clinical and public health interventions. The findings suggest that SDB prevalence has risen substantially, with a growing burden on public health due to the increasing prevalence of obesity. The study also emphasizes the importance of monitoring SDB prevalence to address its serious health consequences, including cardiovascular disease, cognitive decline, mood disorders, and premature death. The study provides updated prevalence estimates for SDB by age, sex, and BMI strata, which can help inform future public health strategies.