The U.S. opioid epidemic continues, with drug overdose deaths nearly tripling from 1999–2014. In 2014, 60.9% of drug overdose deaths involved opioids. From 2014 to 2015, synthetic opioid-involved deaths increased by 72.2%, and heroin deaths by 20.6%. These increases were observed across all demographics and regions. Methadone deaths decreased by 9.1%. The rise in synthetic opioid deaths is largely attributed to illicitly manufactured fentanyl. The report emphasizes the need for a multifaceted approach, including implementing CDC guidelines for opioid prescribing, improving access to prescription drug monitoring programs, expanding naloxone distribution, and enhancing treatment capacity. It also highlights the importance of law enforcement strategies to reduce illicit opioid supply. The findings show that drug overdose death rates increased in 30 states and DC, remained stable in 19, and showed mixed trends in two. The rate of opioid-involved deaths increased by 15.6% from 2014 to 2015, driven by heroin and synthetic opioids. The report also notes that heroin deaths remained stable among males aged 15–24. The findings are subject to limitations, including variations in reporting and potential misclassification of heroin deaths as morphine. The report calls for continued efforts to address the opioid epidemic through public health and law enforcement collaboration.The U.S. opioid epidemic continues, with drug overdose deaths nearly tripling from 1999–2014. In 2014, 60.9% of drug overdose deaths involved opioids. From 2014 to 2015, synthetic opioid-involved deaths increased by 72.2%, and heroin deaths by 20.6%. These increases were observed across all demographics and regions. Methadone deaths decreased by 9.1%. The rise in synthetic opioid deaths is largely attributed to illicitly manufactured fentanyl. The report emphasizes the need for a multifaceted approach, including implementing CDC guidelines for opioid prescribing, improving access to prescription drug monitoring programs, expanding naloxone distribution, and enhancing treatment capacity. It also highlights the importance of law enforcement strategies to reduce illicit opioid supply. The findings show that drug overdose death rates increased in 30 states and DC, remained stable in 19, and showed mixed trends in two. The rate of opioid-involved deaths increased by 15.6% from 2014 to 2015, driven by heroin and synthetic opioids. The report also notes that heroin deaths remained stable among males aged 15–24. The findings are subject to limitations, including variations in reporting and potential misclassification of heroin deaths as morphine. The report calls for continued efforts to address the opioid epidemic through public health and law enforcement collaboration.