This narrative review examines the epidemiology, microbiology, clinical characteristics, treatment, and outcomes of infective endocarditis (IE) caused by *Lactobacillus* species. The study included 77 studies with data from 82 patients, most of whom were male (69.6%) and had a median age of 56 years. Prosthetic valves were present in 16% of patients, and 17.3% had previously used probiotics. The aortic valve was the most commonly affected intracardiac site, followed by the mitral valve. Common clinical presentations included fever (65%), sepsis (27.8%), embolic phenomena (34.6%), heart failure (23.8%), and shock (6.3%). Aminoglycosides and penicillin were the most commonly used antimicrobials for definitive treatment, and surgical management was performed in 53.7% of cases. Overall mortality was 17.1%, with 12.2% of deaths directly attributed to IE. Prosthetic valve IE and the development of shock were independently associated with overall mortality. The study highlights the rarity and complexity of IE caused by *Lactobacillus* species, emphasizing the need for early clinical suspicion and prompt diagnosis and treatment.This narrative review examines the epidemiology, microbiology, clinical characteristics, treatment, and outcomes of infective endocarditis (IE) caused by *Lactobacillus* species. The study included 77 studies with data from 82 patients, most of whom were male (69.6%) and had a median age of 56 years. Prosthetic valves were present in 16% of patients, and 17.3% had previously used probiotics. The aortic valve was the most commonly affected intracardiac site, followed by the mitral valve. Common clinical presentations included fever (65%), sepsis (27.8%), embolic phenomena (34.6%), heart failure (23.8%), and shock (6.3%). Aminoglycosides and penicillin were the most commonly used antimicrobials for definitive treatment, and surgical management was performed in 53.7% of cases. Overall mortality was 17.1%, with 12.2% of deaths directly attributed to IE. Prosthetic valve IE and the development of shock were independently associated with overall mortality. The study highlights the rarity and complexity of IE caused by *Lactobacillus* species, emphasizing the need for early clinical suspicion and prompt diagnosis and treatment.