The article "Inflammation, Oxidative Stress, and Obesity" by Alba Fernández-Sánchez et al. explores the multifactorial nature of obesity, a chronic disease characterized by excessive body fat accumulation. The authors highlight the role of adipose tissue not only as a triglyceride storage organ but also as an endocrine organ that produces adipokines, which play crucial roles in metabolic homeostasis. Adipokines such as leptin, tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and resistin are discussed in detail, detailing their functions, mechanisms of action, and their impact on obesity-related conditions. The article further delves into the mechanisms by which obesity leads to oxidative stress (OS). It explains how obesity increases the production of reactive oxygen species (ROS) through various pathways, including mitochondrial and peroxisomal oxidation of fatty acids, overconsumption of oxygen, and cellular damage from excessive fat accumulation. The authors also discuss the role of diet in ROS production and the decreased antioxidant capacity in obese individuals, which can lead to endothelial dysfunction and other health complications. The paper reviews the epidemiology of obesity, its etiological factors, and the associated health consequences. It emphasizes the importance of public health strategies in preventing obesity and its related complications. Additionally, the article examines the relationship between obesity and OS, noting that OS is a key factor in the development of metabolic syndrome and other obesity-related diseases. Finally, the authors suggest that weight loss through nutritional and pharmacological treatments, along with antioxidant supplementation, may help reduce the risk of obesity-related pathologies.The article "Inflammation, Oxidative Stress, and Obesity" by Alba Fernández-Sánchez et al. explores the multifactorial nature of obesity, a chronic disease characterized by excessive body fat accumulation. The authors highlight the role of adipose tissue not only as a triglyceride storage organ but also as an endocrine organ that produces adipokines, which play crucial roles in metabolic homeostasis. Adipokines such as leptin, tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and resistin are discussed in detail, detailing their functions, mechanisms of action, and their impact on obesity-related conditions. The article further delves into the mechanisms by which obesity leads to oxidative stress (OS). It explains how obesity increases the production of reactive oxygen species (ROS) through various pathways, including mitochondrial and peroxisomal oxidation of fatty acids, overconsumption of oxygen, and cellular damage from excessive fat accumulation. The authors also discuss the role of diet in ROS production and the decreased antioxidant capacity in obese individuals, which can lead to endothelial dysfunction and other health complications. The paper reviews the epidemiology of obesity, its etiological factors, and the associated health consequences. It emphasizes the importance of public health strategies in preventing obesity and its related complications. Additionally, the article examines the relationship between obesity and OS, noting that OS is a key factor in the development of metabolic syndrome and other obesity-related diseases. Finally, the authors suggest that weight loss through nutritional and pharmacological treatments, along with antioxidant supplementation, may help reduce the risk of obesity-related pathologies.