The article "Inflammation and Metabolism in Tissue Repair and Regeneration" by Eming, Wynn, and Martin reviews the complex interplay between inflammation and metabolism in the context of tissue repair and regeneration. The authors highlight the critical role of inflammatory cells in facilitating wound debridement, producing chemokines, metabolites, and growth factors, and their potential to become dysregulated, leading to chronic wounds or fibrosis. They discuss the modular nature of the inflammatory response, which includes an early pro-inflammatory stage, a transition to a reparative phenotype, and the restoration of tissue homeostasis. The review also explores recent advances in live imaging techniques, which have provided insights into the dynamic behavior of inflammatory cells at wound sites, including their behavioral switching from pro-inflammatory to anti-inflammatory states. Additionally, the article examines the role of immune cell metabolism, particularly glycolysis and oxidative phosphorylation, in modulating inflammatory responses and tissue repair. The authors emphasize the importance of understanding the metabolic demands of immune cells during tissue repair and the potential therapeutic opportunities that arise from targeting metabolic pathways in immune cells. Finally, they discuss the emerging concepts in pro-fibrotic mediator blockade and the need for further research to understand the complex interactions between immune cells and stromal cells in tissue repair and regeneration.The article "Inflammation and Metabolism in Tissue Repair and Regeneration" by Eming, Wynn, and Martin reviews the complex interplay between inflammation and metabolism in the context of tissue repair and regeneration. The authors highlight the critical role of inflammatory cells in facilitating wound debridement, producing chemokines, metabolites, and growth factors, and their potential to become dysregulated, leading to chronic wounds or fibrosis. They discuss the modular nature of the inflammatory response, which includes an early pro-inflammatory stage, a transition to a reparative phenotype, and the restoration of tissue homeostasis. The review also explores recent advances in live imaging techniques, which have provided insights into the dynamic behavior of inflammatory cells at wound sites, including their behavioral switching from pro-inflammatory to anti-inflammatory states. Additionally, the article examines the role of immune cell metabolism, particularly glycolysis and oxidative phosphorylation, in modulating inflammatory responses and tissue repair. The authors emphasize the importance of understanding the metabolic demands of immune cells during tissue repair and the potential therapeutic opportunities that arise from targeting metabolic pathways in immune cells. Finally, they discuss the emerging concepts in pro-fibrotic mediator blockade and the need for further research to understand the complex interactions between immune cells and stromal cells in tissue repair and regeneration.