Eming, S. A., Wynn, T. A., & Martin, P. (2017) review the role of inflammation and metabolism in tissue repair and regeneration. They highlight how inflammation is a complex, multi-stage process that is crucial for tissue healing but can become dysregulated, leading to fibrosis. Inflammation involves immune cells that clear debris and produce factors necessary for repair. However, if not properly regulated, it can result in chronic wounds or fibrotic tissue. The authors discuss the importance of metabolic pathways in immune cell function during tissue repair, emphasizing how metabolic adaptation is influenced by both nutrients and immune signals. They also explore how immune cells, such as macrophages, switch between pro-inflammatory and anti-inflammatory states, which impacts tissue repair and fibrosis. The review covers recent findings from model organisms like zebrafish and fruit flies, revealing how immune cells respond to damage signals and how their behavior changes during repair. The authors also discuss the role of type 2 immunity in tissue repair and fibrosis, highlighting the importance of cytokines like IL-4 and IL-13. They emphasize the need for further research to understand the molecular mechanisms underlying tissue repair and fibrosis, as well as the potential for therapeutic interventions targeting these processes. The review concludes with a discussion of future directions in the field, including the role of immune cell metabolism in tissue repair and the need for more targeted therapies to improve wound healing outcomes.Eming, S. A., Wynn, T. A., & Martin, P. (2017) review the role of inflammation and metabolism in tissue repair and regeneration. They highlight how inflammation is a complex, multi-stage process that is crucial for tissue healing but can become dysregulated, leading to fibrosis. Inflammation involves immune cells that clear debris and produce factors necessary for repair. However, if not properly regulated, it can result in chronic wounds or fibrotic tissue. The authors discuss the importance of metabolic pathways in immune cell function during tissue repair, emphasizing how metabolic adaptation is influenced by both nutrients and immune signals. They also explore how immune cells, such as macrophages, switch between pro-inflammatory and anti-inflammatory states, which impacts tissue repair and fibrosis. The review covers recent findings from model organisms like zebrafish and fruit flies, revealing how immune cells respond to damage signals and how their behavior changes during repair. The authors also discuss the role of type 2 immunity in tissue repair and fibrosis, highlighting the importance of cytokines like IL-4 and IL-13. They emphasize the need for further research to understand the molecular mechanisms underlying tissue repair and fibrosis, as well as the potential for therapeutic interventions targeting these processes. The review concludes with a discussion of future directions in the field, including the role of immune cell metabolism in tissue repair and the need for more targeted therapies to improve wound healing outcomes.