The article by Carey N. Lumeng and Alan R. Saltiel reviews the links between obesity and metabolic diseases, emphasizing the role of inflammation. It highlights how obesity triggers a chronic low-grade inflammatory response, known as "metainflammation," which affects multiple organ systems and contributes to insulin resistance, type 2 diabetes, cancer, and pulmonary diseases. The review discusses the cellular and molecular mechanisms of obesity-induced inflammation, including the activation of inflammatory cytokines, recruitment of leukocytes, and the dysregulation of immune responses in metabolic tissues. It also explores the unique nature of obesity-induced inflammation, such as its chronicity and multi-organ involvement, and the role of specific immune cells like macrophages and T cells. The article further examines the impact of obesity on different tissues, including the pancreas, adipose tissue, liver, muscle, and hypothalamus, and the potential therapeutic approaches targeting inflammation to prevent and treat obesity-related diseases.The article by Carey N. Lumeng and Alan R. Saltiel reviews the links between obesity and metabolic diseases, emphasizing the role of inflammation. It highlights how obesity triggers a chronic low-grade inflammatory response, known as "metainflammation," which affects multiple organ systems and contributes to insulin resistance, type 2 diabetes, cancer, and pulmonary diseases. The review discusses the cellular and molecular mechanisms of obesity-induced inflammation, including the activation of inflammatory cytokines, recruitment of leukocytes, and the dysregulation of immune responses in metabolic tissues. It also explores the unique nature of obesity-induced inflammation, such as its chronicity and multi-organ involvement, and the role of specific immune cells like macrophages and T cells. The article further examines the impact of obesity on different tissues, including the pancreas, adipose tissue, liver, muscle, and hypothalamus, and the potential therapeutic approaches targeting inflammation to prevent and treat obesity-related diseases.