The article "Inflammatory Markers and Physical Frailty: Towards Clinical Application" by Yiming Pan and Lina Ma explores the relationship between chronic inflammation and physical frailty in older adults. Global population aging has increased the burden on healthcare systems, and frailty, characterized by decreased physical reserve, is a significant concern. Chronic inflammation is linked to decreased physical function and increased disease risk, and multiple studies suggest that inflammation plays a crucial role in contributing to frailty. The authors review the current understanding of inflammatory markers and their potential for early diagnosis and intervention in frail patients. They highlight the need for reliable and recognized markers to improve geriatric care and discuss the challenges in identifying such markers due to the complex pathophysiology of frailty. The article also reviews the association between physical frailty and chronic inflammation, the etiology of chronic inflammation, and the role of various inflammatory markers such as IL-6, CRP, and TNF-α. It emphasizes the importance of developing biomarkers that can predict frailty and guide clinical interventions. The authors propose the use of an Inflammatory Index Score (IIS) as a potential marker for frailty, which combines IL-6 and TNFR1 and has shown good predictive power in various studies. Finally, they discuss future perspectives, including the need for rigorous clinical trials to confirm the role of inflammatory markers and develop therapeutic targets for managing frailty.The article "Inflammatory Markers and Physical Frailty: Towards Clinical Application" by Yiming Pan and Lina Ma explores the relationship between chronic inflammation and physical frailty in older adults. Global population aging has increased the burden on healthcare systems, and frailty, characterized by decreased physical reserve, is a significant concern. Chronic inflammation is linked to decreased physical function and increased disease risk, and multiple studies suggest that inflammation plays a crucial role in contributing to frailty. The authors review the current understanding of inflammatory markers and their potential for early diagnosis and intervention in frail patients. They highlight the need for reliable and recognized markers to improve geriatric care and discuss the challenges in identifying such markers due to the complex pathophysiology of frailty. The article also reviews the association between physical frailty and chronic inflammation, the etiology of chronic inflammation, and the role of various inflammatory markers such as IL-6, CRP, and TNF-α. It emphasizes the importance of developing biomarkers that can predict frailty and guide clinical interventions. The authors propose the use of an Inflammatory Index Score (IIS) as a potential marker for frailty, which combines IL-6 and TNFR1 and has shown good predictive power in various studies. Finally, they discuss future perspectives, including the need for rigorous clinical trials to confirm the role of inflammatory markers and develop therapeutic targets for managing frailty.