The article "Influence of pH on wound-healing: a new perspective for wound-therapy?" by Lars Alexander Schneider, Andreas Korber, Stephan Grabbe, and Joachim Dissemond, published in 2006, explores the impact of pH on wound healing. The authors highlight that while a low pH (acidic) environment is traditionally considered favorable for wound healing, recent studies have shown that certain healing processes, such as skin graft take-rate, require an alkaline environment. This review summarizes existing literature on the role of pH in the wound environment and its influence on the healing process. It concludes that different pH ranges are necessary for distinct phases of wound healing, emphasizing the need for further systematic data to develop targeted therapeutic strategies. The introduction explains that the pH value, which ranges from 0 to 14, is crucial for biochemical reactions during wound healing and is influenced by endogenous and exogenous factors. The article also discusses the normal pH of skin, the effects of pH on microorganisms, and how therapeutic interventions can alter the pH to improve wound healing.The article "Influence of pH on wound-healing: a new perspective for wound-therapy?" by Lars Alexander Schneider, Andreas Korber, Stephan Grabbe, and Joachim Dissemond, published in 2006, explores the impact of pH on wound healing. The authors highlight that while a low pH (acidic) environment is traditionally considered favorable for wound healing, recent studies have shown that certain healing processes, such as skin graft take-rate, require an alkaline environment. This review summarizes existing literature on the role of pH in the wound environment and its influence on the healing process. It concludes that different pH ranges are necessary for distinct phases of wound healing, emphasizing the need for further systematic data to develop targeted therapeutic strategies. The introduction explains that the pH value, which ranges from 0 to 14, is crucial for biochemical reactions during wound healing and is influenced by endogenous and exogenous factors. The article also discusses the normal pH of skin, the effects of pH on microorganisms, and how therapeutic interventions can alter the pH to improve wound healing.