Eric S. Lander reviews the impact of the human genome sequencing on biomedical research over the past decade. The sequencing of the human genome has significantly advanced our understanding of biological functions, inherited diseases, cancer, and human evolution. It has enabled the identification of genes and proteins, facilitated the study of gene regulation, and provided insights into the genetic basis of diseases. The human genome sequence has also led to the development of new technologies, such as massively parallel sequencing, which has made genome sequencing faster and cheaper. The sequencing of additional genomes has expanded our understanding of human biology and enabled comparative studies. The discovery of non-coding RNA, regulatory elements, and other genomic features has deepened our understanding of gene regulation and evolution. The sequencing of the human genome has also had a major impact on medicine, enabling the identification of genes underlying rare and common diseases, and providing new approaches to the diagnosis and treatment of diseases. The future of genomics in medicine includes the development of personalized medicine, the identification of new therapeutic targets, and the understanding of the genetic basis of complex diseases. The sequencing of the human genome has also led to the development of new technologies and methods for studying the genome, including epigenomic maps, three-dimensional genome structure analysis, and the study of genomic variation. The ultimate goal is to understand all the functional elements encoded in the human genome and to use this knowledge to improve human health.Eric S. Lander reviews the impact of the human genome sequencing on biomedical research over the past decade. The sequencing of the human genome has significantly advanced our understanding of biological functions, inherited diseases, cancer, and human evolution. It has enabled the identification of genes and proteins, facilitated the study of gene regulation, and provided insights into the genetic basis of diseases. The human genome sequence has also led to the development of new technologies, such as massively parallel sequencing, which has made genome sequencing faster and cheaper. The sequencing of additional genomes has expanded our understanding of human biology and enabled comparative studies. The discovery of non-coding RNA, regulatory elements, and other genomic features has deepened our understanding of gene regulation and evolution. The sequencing of the human genome has also had a major impact on medicine, enabling the identification of genes underlying rare and common diseases, and providing new approaches to the diagnosis and treatment of diseases. The future of genomics in medicine includes the development of personalized medicine, the identification of new therapeutic targets, and the understanding of the genetic basis of complex diseases. The sequencing of the human genome has also led to the development of new technologies and methods for studying the genome, including epigenomic maps, three-dimensional genome structure analysis, and the study of genomic variation. The ultimate goal is to understand all the functional elements encoded in the human genome and to use this knowledge to improve human health.