A new approach is introduced for tissue engineering using injectable MSC spheroid and microgel granular composites. This method combines MSC spheroids with hyaluronic acid microgels to create injectable, stable composites that support cell-cell interactions, promote spheroid fusion, and allow for interparticle crosslinking via light. These composites are particularly useful for cartilage tissue engineering, where cell-cell interactions are crucial for chondrogenesis. The study demonstrates that granular composites with specific MSC spheroid to microgel volume ratios (20:80, 35:65, 50:50) produce engineered cartilage with extensive matrix deposition and mechanical properties similar to native cartilage. The composites are injectable, mechanically stable, and support long-term chondrogenic cultures. The study also shows that granular composites integrate well with native tissue, with enhanced integration strength compared to hydrogels alone. The results indicate that this approach offers a promising strategy for tissue engineering, combining the benefits of cell-cell interactions through spheroids with the mechanical support of engineered hydrogels. The study highlights the importance of microgel connectivity for construct stability and tissue formation. The granular composites show high porosity, mechanical strength, and ECM deposition, making them suitable for cartilage tissue engineering. The study also discusses the potential for future improvements in integration with damaged cartilage and the need for further research to assess the composites in pre-clinical cartilage defects.A new approach is introduced for tissue engineering using injectable MSC spheroid and microgel granular composites. This method combines MSC spheroids with hyaluronic acid microgels to create injectable, stable composites that support cell-cell interactions, promote spheroid fusion, and allow for interparticle crosslinking via light. These composites are particularly useful for cartilage tissue engineering, where cell-cell interactions are crucial for chondrogenesis. The study demonstrates that granular composites with specific MSC spheroid to microgel volume ratios (20:80, 35:65, 50:50) produce engineered cartilage with extensive matrix deposition and mechanical properties similar to native cartilage. The composites are injectable, mechanically stable, and support long-term chondrogenic cultures. The study also shows that granular composites integrate well with native tissue, with enhanced integration strength compared to hydrogels alone. The results indicate that this approach offers a promising strategy for tissue engineering, combining the benefits of cell-cell interactions through spheroids with the mechanical support of engineered hydrogels. The study highlights the importance of microgel connectivity for construct stability and tissue formation. The granular composites show high porosity, mechanical strength, and ECM deposition, making them suitable for cartilage tissue engineering. The study also discusses the potential for future improvements in integration with damaged cartilage and the need for further research to assess the composites in pre-clinical cartilage defects.