InnateDB is an integrated analysis platform designed for systems-level studies of mammalian innate immunity. It contains over 196,000 experimentally validated molecular interactions and 3,000 pathway annotations relevant to all mammalian cellular systems. The database has been manually curated with over 18,000 interactions relevant to innate immunity, providing deep insights into innate immunity networks and pathways. Recent updates include the curation of allergy and asthma-related interactions, and improvements in bioinformatics solutions such as web service access, enhanced Gene Ontology analysis, and new network visualization tools. The integration of bovine data makes InnateDB the first integrated network analysis platform for this important model organism. InnateDB curates molecular interactions, pathways, and their components, with over 43,000 publications reviewed and over 18,000 interactions annotated. It also provides a comprehensive list of genes involved in innate immunity, with over 1,500 genes. InnateDB is a member of the International Molecular Exchange Consortium (IMEx) and curates interactions from Nature Immunology using IMEx standards. It also integrates data from external resources, including genome, interaction, and pathway databases, providing over 178,000 experimentally validated interactions. InnateDB uses orthology-based approaches to predict bovine pathways and interactions from human data, enabling the study of bovine innate immunity. It also transfers human and mouse pathway annotations to bovine genes, providing annotations for 7,032 bovine genes. The database includes over 70,000 bovine interologs and 1,536 human pathways with a high conservation rate. InnateDB offers data analysis and visualization tools, allowing users to search for genes, pathways, and interactions, and to build and analyze molecular interaction networks. It supports PSICQUIC web services for querying interaction data, and provides data in various formats. Ongoing developments include expanding beyond innate immunity to include adaptive immunity data and developing a new portal for allergy and asthma research. Future improvements include enhancing pathway analysis tools and expanding data integration. Funding comes from various sources, including Genome BC, the National Institutes of Health, and Teagasc.InnateDB is an integrated analysis platform designed for systems-level studies of mammalian innate immunity. It contains over 196,000 experimentally validated molecular interactions and 3,000 pathway annotations relevant to all mammalian cellular systems. The database has been manually curated with over 18,000 interactions relevant to innate immunity, providing deep insights into innate immunity networks and pathways. Recent updates include the curation of allergy and asthma-related interactions, and improvements in bioinformatics solutions such as web service access, enhanced Gene Ontology analysis, and new network visualization tools. The integration of bovine data makes InnateDB the first integrated network analysis platform for this important model organism. InnateDB curates molecular interactions, pathways, and their components, with over 43,000 publications reviewed and over 18,000 interactions annotated. It also provides a comprehensive list of genes involved in innate immunity, with over 1,500 genes. InnateDB is a member of the International Molecular Exchange Consortium (IMEx) and curates interactions from Nature Immunology using IMEx standards. It also integrates data from external resources, including genome, interaction, and pathway databases, providing over 178,000 experimentally validated interactions. InnateDB uses orthology-based approaches to predict bovine pathways and interactions from human data, enabling the study of bovine innate immunity. It also transfers human and mouse pathway annotations to bovine genes, providing annotations for 7,032 bovine genes. The database includes over 70,000 bovine interologs and 1,536 human pathways with a high conservation rate. InnateDB offers data analysis and visualization tools, allowing users to search for genes, pathways, and interactions, and to build and analyze molecular interaction networks. It supports PSICQUIC web services for querying interaction data, and provides data in various formats. Ongoing developments include expanding beyond innate immunity to include adaptive immunity data and developing a new portal for allergy and asthma research. Future improvements include enhancing pathway analysis tools and expanding data integration. Funding comes from various sources, including Genome BC, the National Institutes of Health, and Teagasc.