InnateDB is an integrated analysis platform designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways, and genes. The platform has recently been updated to include over 196,000 experimentally validated molecular interactions and 3,000 pathway annotations relevant to all mammalian cellular systems. The InnateDB team has manually curated over 18,000 molecular interactions relevant to innate immunity, providing insights into the complex networks and pathways involved. Additionally, InnateDB has initiated the curation of allergy- and asthma-related interactions. Recent improvements include web service access to interaction data using Proteomics Standards Initiative Common Query Interface, enhanced Gene Ontology analysis for innate immunity, and new network visualization tools. The integration of bovine data makes InnateDB the first integrated network analysis platform for this agriculturally important model organism. The platform continues to provide a comprehensive resource for systems and network biology analyses of innate immune-associated responses, with ongoing developments focusing on expanding adaptive immunity information and improving pathway analysis tools.InnateDB is an integrated analysis platform designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways, and genes. The platform has recently been updated to include over 196,000 experimentally validated molecular interactions and 3,000 pathway annotations relevant to all mammalian cellular systems. The InnateDB team has manually curated over 18,000 molecular interactions relevant to innate immunity, providing insights into the complex networks and pathways involved. Additionally, InnateDB has initiated the curation of allergy- and asthma-related interactions. Recent improvements include web service access to interaction data using Proteomics Standards Initiative Common Query Interface, enhanced Gene Ontology analysis for innate immunity, and new network visualization tools. The integration of bovine data makes InnateDB the first integrated network analysis platform for this agriculturally important model organism. The platform continues to provide a comprehensive resource for systems and network biology analyses of innate immune-associated responses, with ongoing developments focusing on expanding adaptive immunity information and improving pathway analysis tools.