This review explores the impact of ChatGPT on rare disorder management in medicine. ChatGPT, a large language model developed by OpenAI, has shown promise in various medical fields, including rheumatology, oncology, psychiatry, internal medicine, and ophthalmology. However, its application in genetics and rare disorders remains underexplored due to the complexity of these conditions and the need for personalized patient care. The review highlights ChatGPT's potential in research, education, and clinical practice, emphasizing its ability to generate human-like responses, assist in diagnosis, and provide treatment recommendations. Despite its strengths, ChatGPT has limitations, including the risk of providing inaccurate or misleading information, particularly for rare diseases. The review also discusses the ethical concerns surrounding the use of AI in healthcare, such as the lack of transparency, potential for bias, and the need for human oversight. While ChatGPT can support medical professionals in various tasks, such as drafting medical records and providing diagnostic suggestions, it cannot replace human expertise. The review concludes that ChatGPT has significant potential in healthcare, but its use must be carefully managed to ensure accuracy and reliability, especially in the context of rare disorders. The integration of AI into healthcare requires careful consideration of its benefits and limitations to ensure that it enhances, rather than compromises, patient care.This review explores the impact of ChatGPT on rare disorder management in medicine. ChatGPT, a large language model developed by OpenAI, has shown promise in various medical fields, including rheumatology, oncology, psychiatry, internal medicine, and ophthalmology. However, its application in genetics and rare disorders remains underexplored due to the complexity of these conditions and the need for personalized patient care. The review highlights ChatGPT's potential in research, education, and clinical practice, emphasizing its ability to generate human-like responses, assist in diagnosis, and provide treatment recommendations. Despite its strengths, ChatGPT has limitations, including the risk of providing inaccurate or misleading information, particularly for rare diseases. The review also discusses the ethical concerns surrounding the use of AI in healthcare, such as the lack of transparency, potential for bias, and the need for human oversight. While ChatGPT can support medical professionals in various tasks, such as drafting medical records and providing diagnostic suggestions, it cannot replace human expertise. The review concludes that ChatGPT has significant potential in healthcare, but its use must be carefully managed to ensure accuracy and reliability, especially in the context of rare disorders. The integration of AI into healthcare requires careful consideration of its benefits and limitations to ensure that it enhances, rather than compromises, patient care.