This review explores the impact of ChatGPT on the management of rare disorders in medicine. ChatGPT, a large language model developed by OpenAI, has gained prominence for its ability to generate human-like responses using deep learning techniques. The review highlights the potential applications of ChatGPT in various medical specialties, including genetics and rare disorders, and discusses its benefits and limitations. While ChatGPT can assist in research, education, and clinical practice, it faces challenges such as frequency bias, hallucinations, and the need for human supervision. The review emphasizes the importance of integrating ChatGPT with expert human judgment to ensure accurate and reliable medical decisions. The authors suggest that tailored training on rare disorders could enhance ChatGPT's performance and support medical professionals in identifying and managing rare conditions. Overall, the review aims to pave the way for a healthcare system that is more knowledgeable, efficient, and patient-centered.This review explores the impact of ChatGPT on the management of rare disorders in medicine. ChatGPT, a large language model developed by OpenAI, has gained prominence for its ability to generate human-like responses using deep learning techniques. The review highlights the potential applications of ChatGPT in various medical specialties, including genetics and rare disorders, and discusses its benefits and limitations. While ChatGPT can assist in research, education, and clinical practice, it faces challenges such as frequency bias, hallucinations, and the need for human supervision. The review emphasizes the importance of integrating ChatGPT with expert human judgment to ensure accurate and reliable medical decisions. The authors suggest that tailored training on rare disorders could enhance ChatGPT's performance and support medical professionals in identifying and managing rare conditions. Overall, the review aims to pave the way for a healthcare system that is more knowledgeable, efficient, and patient-centered.