The chapter introduces the concept of Input-to-State Stability (ISS) in the analysis and design of nonlinear feedback systems. The author, E.D. Sontag, emphasizes the recent progress in this field, driven by the discovery of fundamental concepts and the identification of systematic decomposition approaches for effective control laws. The focus is on robustness questions with respect to disturbances, formulated within the ISS paradigm. The chapter provides an intuitive overview of the main concepts and highlights recent developments, while also referencing older results and surveys. It aims to develop a toolkit of concepts for studying systems via decompositions, quantify system response to external signals, and unify state-space and input/output stability theories. The chapter outlines the desirable properties of stability, including the behavior of bounded, eventually small, integrally small, or convergent inputs leading to corresponding outputs, while also accounting for initial states and transients.The chapter introduces the concept of Input-to-State Stability (ISS) in the analysis and design of nonlinear feedback systems. The author, E.D. Sontag, emphasizes the recent progress in this field, driven by the discovery of fundamental concepts and the identification of systematic decomposition approaches for effective control laws. The focus is on robustness questions with respect to disturbances, formulated within the ISS paradigm. The chapter provides an intuitive overview of the main concepts and highlights recent developments, while also referencing older results and surveys. It aims to develop a toolkit of concepts for studying systems via decompositions, quantify system response to external signals, and unify state-space and input/output stability theories. The chapter outlines the desirable properties of stability, including the behavior of bounded, eventually small, integrally small, or convergent inputs leading to corresponding outputs, while also accounting for initial states and transients.