The cBioPortal for Cancer Genomics is a web resource designed to facilitate the exploration, visualization, and analysis of multidimensional cancer genomics data. It integrates various genomic data types, including somatic mutations, DNA copy-number alterations (CNAs), mRNA and microRNA (miRNA) expression, DNA methylation, protein abundance, and phosphoprotein abundance. The portal provides an intuitive interface for researchers and clinicians to interactively explore genetic alterations across samples, genes, and pathways, and to link these alterations to clinical outcomes. Key features include graphical summaries, network visualization, survival analysis, patient-centric queries, and programmatic access. The portal supports cross-cancer queries, allowing users to assess alteration frequencies and mutation data across multiple cancer types. It also offers detailed summaries of individual cancer studies, including clinical details, genomic data, and recurrently mutated genes. The cBioPortal aims to complement existing tools and resources, such as genome browsers, by providing an exploratory analysis platform for cancer genomics data. Future developments include additional cancer studies, support for methylation events, improved network visualization, and enhanced patient view features.The cBioPortal for Cancer Genomics is a web resource designed to facilitate the exploration, visualization, and analysis of multidimensional cancer genomics data. It integrates various genomic data types, including somatic mutations, DNA copy-number alterations (CNAs), mRNA and microRNA (miRNA) expression, DNA methylation, protein abundance, and phosphoprotein abundance. The portal provides an intuitive interface for researchers and clinicians to interactively explore genetic alterations across samples, genes, and pathways, and to link these alterations to clinical outcomes. Key features include graphical summaries, network visualization, survival analysis, patient-centric queries, and programmatic access. The portal supports cross-cancer queries, allowing users to assess alteration frequencies and mutation data across multiple cancer types. It also offers detailed summaries of individual cancer studies, including clinical details, genomic data, and recurrently mutated genes. The cBioPortal aims to complement existing tools and resources, such as genome browsers, by providing an exploratory analysis platform for cancer genomics data. Future developments include additional cancer studies, support for methylation events, improved network visualization, and enhanced patient view features.