The Surviving Sepsis Campaign (SSC) aimed to improve severe sepsis care through a global performance improvement initiative based on evidence-based guidelines. The campaign involved hospitals in the US, Europe, and South America, implementing bundles of care to achieve specific targets within 6 hours (resuscitation bundle) and 24 hours (management bundle). Data from 15,022 patients across 165 sites showed a significant increase in compliance with these bundles over two years, from 10.9% to 31.3% for the resuscitation bundle and 18.4% to 36.1% for the management bundle. Hospital mortality decreased from 37% to 30.8% over the same period, with adjusted odds ratios indicating a 5.4% reduction in mortality over two years. The study highlights the effectiveness of guideline-based performance improvement in improving sepsis care, although causality could not be definitively established. The results suggest that adherence to bundle targets is associated with better patient outcomes, and the campaign's success underscores the importance of implementing evidence-based guidelines in clinical practice. The study also notes that while the campaign improved compliance and outcomes, further research is needed to confirm the specific components of the bundles that contribute to mortality reduction. The findings support the need for global efforts to improve sepsis care through standardized, guideline-based interventions.The Surviving Sepsis Campaign (SSC) aimed to improve severe sepsis care through a global performance improvement initiative based on evidence-based guidelines. The campaign involved hospitals in the US, Europe, and South America, implementing bundles of care to achieve specific targets within 6 hours (resuscitation bundle) and 24 hours (management bundle). Data from 15,022 patients across 165 sites showed a significant increase in compliance with these bundles over two years, from 10.9% to 31.3% for the resuscitation bundle and 18.4% to 36.1% for the management bundle. Hospital mortality decreased from 37% to 30.8% over the same period, with adjusted odds ratios indicating a 5.4% reduction in mortality over two years. The study highlights the effectiveness of guideline-based performance improvement in improving sepsis care, although causality could not be definitively established. The results suggest that adherence to bundle targets is associated with better patient outcomes, and the campaign's success underscores the importance of implementing evidence-based guidelines in clinical practice. The study also notes that while the campaign improved compliance and outcomes, further research is needed to confirm the specific components of the bundles that contribute to mortality reduction. The findings support the need for global efforts to improve sepsis care through standardized, guideline-based interventions.