The article discusses the importance of interdisciplinary fetal-neonatal neurology (FNN) training in understanding and addressing the neural exposome, which encompasses the dynamic changes in the nervous system throughout the first 1,000 days of life. This training integrates perspectives from reproductive health, pregnancy, neonatal care, and adult neurology, emphasizing the impact of toxic stressor interplay (TSI) on neurodevelopment. The curriculum aims to strengthen diagnostic and therapeutic skills, reduce bias, and improve patient outcomes. Key aspects include: 1. **Neural Exposome Concept**: The neural exposome integrates environmental neuroscience with life-course neurologic diagnostic strategies, focusing on the dynamic interactions between genes and environment. 2. **Reproductive and Pregnancy Health**: Preconception and prenatal adversities can significantly impact brain health, with endogenous and exogenous toxic stressors altering the neural exposome through maladaptive developmental neuroplasticity. 3. **Prenatal and Neonatal Care**: FNN training enhances neonatal neurocritical care, integrating maternal and pediatric healthcare priorities to better manage complex prenatal-to-neonatal disease pathways. 4. **Developmental and Adult Neurology**: The principles of FNN are applied to pediatric and adult neurology, improving diagnostic accuracy and therapeutic interventions for neurological disorders across the lifespan. 5. **Social Determinants of Health**: Addressing social determinants of health is crucial for equitable healthcare delivery, particularly in high-risk populations such as those in the Global South and high-income country medical deserts. 6. **Exposome Research**: Advances in exposome research promise improved disease monitoring and drug delivery, starting during pregnancy, and support the development of life-course perspectives of the neural exposome. 7. **Intervention Strategies**: Effective interventions, including early intervention referrals, multidisciplinary consultations, and person-centered educational plans, are essential for improving outcomes in children with neurological disorders. 8. **Ethical Considerations**: Bioethical discussions and interdisciplinary collaborations are vital for making informed decisions and ensuring equitable healthcare practices. 9. **Training Organization**: A comprehensive two-year FNN training program is proposed, integrating clinical and didactic instruction from multiple specialties to enhance diagnostic and therapeutic skills. 10. **Placental Exposome**: The placental exposome plays a crucial role in fetal brain development, with placental diseases contributing to fetal brain anomalies and destructive lesions. Overall, the article emphasizes the need for a holistic approach to neurology training that integrates the neural exposome concept, addressing the complex interplay of genetic, environmental, and social factors to improve neurological health across the lifespan.The article discusses the importance of interdisciplinary fetal-neonatal neurology (FNN) training in understanding and addressing the neural exposome, which encompasses the dynamic changes in the nervous system throughout the first 1,000 days of life. This training integrates perspectives from reproductive health, pregnancy, neonatal care, and adult neurology, emphasizing the impact of toxic stressor interplay (TSI) on neurodevelopment. The curriculum aims to strengthen diagnostic and therapeutic skills, reduce bias, and improve patient outcomes. Key aspects include: 1. **Neural Exposome Concept**: The neural exposome integrates environmental neuroscience with life-course neurologic diagnostic strategies, focusing on the dynamic interactions between genes and environment. 2. **Reproductive and Pregnancy Health**: Preconception and prenatal adversities can significantly impact brain health, with endogenous and exogenous toxic stressors altering the neural exposome through maladaptive developmental neuroplasticity. 3. **Prenatal and Neonatal Care**: FNN training enhances neonatal neurocritical care, integrating maternal and pediatric healthcare priorities to better manage complex prenatal-to-neonatal disease pathways. 4. **Developmental and Adult Neurology**: The principles of FNN are applied to pediatric and adult neurology, improving diagnostic accuracy and therapeutic interventions for neurological disorders across the lifespan. 5. **Social Determinants of Health**: Addressing social determinants of health is crucial for equitable healthcare delivery, particularly in high-risk populations such as those in the Global South and high-income country medical deserts. 6. **Exposome Research**: Advances in exposome research promise improved disease monitoring and drug delivery, starting during pregnancy, and support the development of life-course perspectives of the neural exposome. 7. **Intervention Strategies**: Effective interventions, including early intervention referrals, multidisciplinary consultations, and person-centered educational plans, are essential for improving outcomes in children with neurological disorders. 8. **Ethical Considerations**: Bioethical discussions and interdisciplinary collaborations are vital for making informed decisions and ensuring equitable healthcare practices. 9. **Training Organization**: A comprehensive two-year FNN training program is proposed, integrating clinical and didactic instruction from multiple specialties to enhance diagnostic and therapeutic skills. 10. **Placental Exposome**: The placental exposome plays a crucial role in fetal brain development, with placental diseases contributing to fetal brain anomalies and destructive lesions. Overall, the article emphasizes the need for a holistic approach to neurology training that integrates the neural exposome concept, addressing the complex interplay of genetic, environmental, and social factors to improve neurological health across the lifespan.