The article reviews the signaling mechanisms of IL-6-type cytokines through the gp130/Jak/STAT pathway. These cytokines, including IL-6, IL-11, LIF, OSM, CNTF, CT-1, and Epo, play crucial roles in regulating cellular processes such as gene activation, proliferation, and differentiation. The review focuses on the assembly of receptor complexes after ligand binding, the activation of Janus kinases (Jaks), and the recruitment and phosphorylation of STAT proteins. Key players in the signaling pathway, including cytokines, receptor components, Jaks (Jak1, Jak2, and Tyk2), STAT1 and STAT3, and the tyrosine phosphatase SHP2, are discussed in detail. The article also covers various mechanisms involved in the termination of IL-6-type cytokine signaling, such as the action of tyrosine phosphatases, proteasome, Jak kinase inhibitors (SOCS), protein inhibitors of activated STATs (PIAS), and internalization of cytokine receptors via gp130. Despite their shared signaling pathway, different IL-6-type cytokines elicit distinct biological responses, as evidenced by the phenotypes of cytokine knockout animals.The article reviews the signaling mechanisms of IL-6-type cytokines through the gp130/Jak/STAT pathway. These cytokines, including IL-6, IL-11, LIF, OSM, CNTF, CT-1, and Epo, play crucial roles in regulating cellular processes such as gene activation, proliferation, and differentiation. The review focuses on the assembly of receptor complexes after ligand binding, the activation of Janus kinases (Jaks), and the recruitment and phosphorylation of STAT proteins. Key players in the signaling pathway, including cytokines, receptor components, Jaks (Jak1, Jak2, and Tyk2), STAT1 and STAT3, and the tyrosine phosphatase SHP2, are discussed in detail. The article also covers various mechanisms involved in the termination of IL-6-type cytokine signaling, such as the action of tyrosine phosphatases, proteasome, Jak kinase inhibitors (SOCS), protein inhibitors of activated STATs (PIAS), and internalization of cytokine receptors via gp130. Despite their shared signaling pathway, different IL-6-type cytokines elicit distinct biological responses, as evidenced by the phenotypes of cytokine knockout animals.