Interleukins (ILs) play a significant role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). ILs are cytokines that influence immune responses and can be pro-inflammatory or anti-inflammatory. The study highlights the involvement of various ILs, including IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, and IL-10, in the development and progression of NAFLD. IL-1 is particularly important in inflammation and NASH, while IL-6 is involved in insulin resistance and liver inflammation. The study also discusses the role of IL-2 in NASH diagnosis and the potential of IL-4 in immune regulation. The findings suggest that understanding the roles of these ILs could lead to new therapeutic strategies for NAFLD. The study emphasizes the need for further research to clarify the mechanisms by which ILs contribute to NAFLD and to develop effective treatments. The results indicate that targeting specific ILs may offer promising therapeutic options for NAFLD.Interleukins (ILs) play a significant role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). ILs are cytokines that influence immune responses and can be pro-inflammatory or anti-inflammatory. The study highlights the involvement of various ILs, including IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, and IL-10, in the development and progression of NAFLD. IL-1 is particularly important in inflammation and NASH, while IL-6 is involved in insulin resistance and liver inflammation. The study also discusses the role of IL-2 in NASH diagnosis and the potential of IL-4 in immune regulation. The findings suggest that understanding the roles of these ILs could lead to new therapeutic strategies for NAFLD. The study emphasizes the need for further research to clarify the mechanisms by which ILs contribute to NAFLD and to develop effective treatments. The results indicate that targeting specific ILs may offer promising therapeutic options for NAFLD.