This article presents the first evidence-based and expert consensus recommendations for point-of-care lung ultrasound, focusing on emergency and critical care settings. A multidisciplinary panel of 28 experts from eight countries reviewed literature from January 1966 to June 2011. The recommendations were developed using the Grading of Recommendation Assessment, Development, and Evaluation (GRADE) method and the RAND Appropriateness Method for panel judgment and decisions. After three conferences in Bologna, Pisa, and Rome, 73 proposed statements were discussed and categorized into strong or weak/conditional recommendations. The recommendations cover various aspects of lung ultrasound, including pneumothorax, interstitial syndrome, lung consolidation, monitoring lung diseases, neonatology and pediatrics, and pleural effusion. The document aims to guide implementation, development, and standardization of lung ultrasound in all relevant settings and will be updated at least every 4 years or whenever significant changes in evidence occur.This article presents the first evidence-based and expert consensus recommendations for point-of-care lung ultrasound, focusing on emergency and critical care settings. A multidisciplinary panel of 28 experts from eight countries reviewed literature from January 1966 to June 2011. The recommendations were developed using the Grading of Recommendation Assessment, Development, and Evaluation (GRADE) method and the RAND Appropriateness Method for panel judgment and decisions. After three conferences in Bologna, Pisa, and Rome, 73 proposed statements were discussed and categorized into strong or weak/conditional recommendations. The recommendations cover various aspects of lung ultrasound, including pneumothorax, interstitial syndrome, lung consolidation, monitoring lung diseases, neonatology and pediatrics, and pleural effusion. The document aims to guide implementation, development, and standardization of lung ultrasound in all relevant settings and will be updated at least every 4 years or whenever significant changes in evidence occur.