The International Cancer Genome Consortium (ICGC) was established to coordinate large-scale cancer genome studies across 50 different cancer types and subtypes globally. The consortium aims to systematically study over 25,000 cancer genomes at the genomic, epigenomic, and transcriptomic levels to uncover oncogenic mutations, identify clinically relevant subtypes, and develop new cancer therapies. The ICGC emphasizes the importance of high-quality data, comprehensive coverage, and the integration of transcriptomic and epigenomic data. Ethical considerations, such as informed consent and data access policies, are integral to the consortium's operations. The ICGC has adopted a 'franchise' database model to manage and share data, ensuring both public access and controlled access for specific analyses. The consortium also collaborates with other initiatives like the Cancer Genome Atlas (TCGA) to ensure coordinated efforts and data sharing. The ICGC's long-term goal is to translate cancer genome research into clinical practice, addressing challenges related to data complexity and technological limitations.The International Cancer Genome Consortium (ICGC) was established to coordinate large-scale cancer genome studies across 50 different cancer types and subtypes globally. The consortium aims to systematically study over 25,000 cancer genomes at the genomic, epigenomic, and transcriptomic levels to uncover oncogenic mutations, identify clinically relevant subtypes, and develop new cancer therapies. The ICGC emphasizes the importance of high-quality data, comprehensive coverage, and the integration of transcriptomic and epigenomic data. Ethical considerations, such as informed consent and data access policies, are integral to the consortium's operations. The ICGC has adopted a 'franchise' database model to manage and share data, ensuring both public access and controlled access for specific analyses. The consortium also collaborates with other initiatives like the Cancer Genome Atlas (TCGA) to ensure coordinated efforts and data sharing. The ICGC's long-term goal is to translate cancer genome research into clinical practice, addressing challenges related to data complexity and technological limitations.