The study analyzed 200 serum specimens from patients undergoing liver function tests, revealing significant variations in protein concentrations. Calcium levels correlated strongly with albumin (r = 0.867) but less so with total protein (r = 0.682). A formula was derived to adjust calcium levels based on albumin: Adjusted calcium = calcium - albumin + 4.0. This adjustment normalized calcium levels in 39 specimens with hypergammaglobulinaemia. The 95% confidence limits for adjusted calcium matched the normal range. The study emphasized the importance of adjusting calcium measurements for protein concentrations, particularly albumin, due to its strong correlation with calcium. Adjustments based on total protein were less effective in cases of abnormal protein distribution. The study also highlighted the need for accurate calcium measurement in patients with abnormal protein levels, as these can affect total calcium readings. The findings suggest that adjusting calcium levels for albumin provides a more reliable assessment of calcium status in patients with abnormal protein concentrations. The study concluded that interpreting serum calcium without protein measurements is unreliable, and adjustments based on albumin are preferable to those based on total protein or specific gravity. The research underscores the importance of considering protein concentrations when interpreting calcium levels, especially in patients with abnormal protein profiles. The study also noted that true hypocalcaemia is more common than hypercalcaemia, and that adjustments based on albumin provide a more accurate reflection of calcium status. The study's findings have implications for clinical practice, emphasizing the need for careful interpretation of calcium levels in patients with abnormal protein concentrations. The study was conducted on serum specimens where liver function tests were requested but calcium analysis was not, due to the high prevalence of abnormal protein concentrations and low prevalence of calcium disorders. The study's results support the hypothesis that adjusting calcium levels for albumin provides a more accurate assessment of calcium status in patients with abnormal protein concentrations. The study also noted that the adjustment formula is easy to remember and apply, and that it should not be used in patients with nephrotic syndrome and hypoalbuminaemia. The study's findings have implications for clinical practice, emphasizing the need for careful interpretation of calcium levels in patients with abnormal protein concentrations. The study concluded that interpreting serum calcium without protein measurements is unreliable, and that adjustments based on albumin are preferable to those based on total protein or specific gravity. The study's findings have implications for clinical practice, emphasizing the need for careful interpretation of calcium levels in patients with abnormal protein concentrations. The study also noted that the adjustment formula is easy to remember and apply, and that it should not be used in patients with nephrotic syndrome and hypoalbuminaemia. The study's findings have implications for clinical practice, emphasizing the need for careful interpretation of calcium levels in patients with abnormal protein concentrations. The study concluded that interpreting serum calcium without protein measurements is unreliable, and that adjustments based on albumin are preferable to those based on total protein orThe study analyzed 200 serum specimens from patients undergoing liver function tests, revealing significant variations in protein concentrations. Calcium levels correlated strongly with albumin (r = 0.867) but less so with total protein (r = 0.682). A formula was derived to adjust calcium levels based on albumin: Adjusted calcium = calcium - albumin + 4.0. This adjustment normalized calcium levels in 39 specimens with hypergammaglobulinaemia. The 95% confidence limits for adjusted calcium matched the normal range. The study emphasized the importance of adjusting calcium measurements for protein concentrations, particularly albumin, due to its strong correlation with calcium. Adjustments based on total protein were less effective in cases of abnormal protein distribution. The study also highlighted the need for accurate calcium measurement in patients with abnormal protein levels, as these can affect total calcium readings. The findings suggest that adjusting calcium levels for albumin provides a more reliable assessment of calcium status in patients with abnormal protein concentrations. The study concluded that interpreting serum calcium without protein measurements is unreliable, and adjustments based on albumin are preferable to those based on total protein or specific gravity. The research underscores the importance of considering protein concentrations when interpreting calcium levels, especially in patients with abnormal protein profiles. The study also noted that true hypocalcaemia is more common than hypercalcaemia, and that adjustments based on albumin provide a more accurate reflection of calcium status. The study's findings have implications for clinical practice, emphasizing the need for careful interpretation of calcium levels in patients with abnormal protein concentrations. The study was conducted on serum specimens where liver function tests were requested but calcium analysis was not, due to the high prevalence of abnormal protein concentrations and low prevalence of calcium disorders. The study's results support the hypothesis that adjusting calcium levels for albumin provides a more accurate assessment of calcium status in patients with abnormal protein concentrations. The study also noted that the adjustment formula is easy to remember and apply, and that it should not be used in patients with nephrotic syndrome and hypoalbuminaemia. The study's findings have implications for clinical practice, emphasizing the need for careful interpretation of calcium levels in patients with abnormal protein concentrations. The study concluded that interpreting serum calcium without protein measurements is unreliable, and that adjustments based on albumin are preferable to those based on total protein or specific gravity. The study's findings have implications for clinical practice, emphasizing the need for careful interpretation of calcium levels in patients with abnormal protein concentrations. The study also noted that the adjustment formula is easy to remember and apply, and that it should not be used in patients with nephrotic syndrome and hypoalbuminaemia. The study's findings have implications for clinical practice, emphasizing the need for careful interpretation of calcium levels in patients with abnormal protein concentrations. The study concluded that interpreting serum calcium without protein measurements is unreliable, and that adjustments based on albumin are preferable to those based on total protein or