The study by Akey et al. (2002) aims to identify genomic regions that have been targets of natural selection by analyzing 26,530 single nucleotide polymorphisms (SNPs) with allele frequencies determined in three populations: African-American, East Asian, and European-American. The authors calculated the genetic differentiation measure, FST, for each locus and examined its distribution at different levels of the genome, chromosomes, and individual genes. They found statistically significant evidence supporting the hypothesis that selection has influenced patterns of human genetic variation. By contrasting the FST of individual SNPs with the empirical genome-wide distribution of FST, they identified 174 candidate genes with distribution patterns indicating selection. This work provides a high-resolution natural selection map of the human genome, offering insights into the evolutionary history of humans and facilitating studies on the identified candidate genes. The study also discusses the limitations and future directions for further research.The study by Akey et al. (2002) aims to identify genomic regions that have been targets of natural selection by analyzing 26,530 single nucleotide polymorphisms (SNPs) with allele frequencies determined in three populations: African-American, East Asian, and European-American. The authors calculated the genetic differentiation measure, FST, for each locus and examined its distribution at different levels of the genome, chromosomes, and individual genes. They found statistically significant evidence supporting the hypothesis that selection has influenced patterns of human genetic variation. By contrasting the FST of individual SNPs with the empirical genome-wide distribution of FST, they identified 174 candidate genes with distribution patterns indicating selection. This work provides a high-resolution natural selection map of the human genome, offering insights into the evolutionary history of humans and facilitating studies on the identified candidate genes. The study also discusses the limitations and future directions for further research.