This review evaluates interventions for latent autoimmune diabetes (LADA) in adults, a condition that initially presents as type 2 diabetes but progresses to insulin-dependent diabetes. The study includes 15 publications (10 studies) involving 1019 participants, with follow-up periods ranging from three months to 10 years. The interventions examined include insulin alone, insulin combined with sulphonylureas (SUs), vitamin D, Chinese medicine, and rosiglitazone. The main findings indicate that SUs do not improve metabolic control more effectively than insulin alone and may lead to earlier insulin dependence. Insulin combined with vitamin D or Chinese medicine may maintain natural insulin production better than insulin alone. However, there is no significant evidence to support or refute other interventions. The review highlights the need for further studies with clear definitions of LADA, focusing on patient-important outcomes and standardized methods for measuring C-peptide levels.This review evaluates interventions for latent autoimmune diabetes (LADA) in adults, a condition that initially presents as type 2 diabetes but progresses to insulin-dependent diabetes. The study includes 15 publications (10 studies) involving 1019 participants, with follow-up periods ranging from three months to 10 years. The interventions examined include insulin alone, insulin combined with sulphonylureas (SUs), vitamin D, Chinese medicine, and rosiglitazone. The main findings indicate that SUs do not improve metabolic control more effectively than insulin alone and may lead to earlier insulin dependence. Insulin combined with vitamin D or Chinese medicine may maintain natural insulin production better than insulin alone. However, there is no significant evidence to support or refute other interventions. The review highlights the need for further studies with clear definitions of LADA, focusing on patient-important outcomes and standardized methods for measuring C-peptide levels.