This review focuses on the latest advancements in using injectable hydrogels for targeted drug delivery to promote cartilage repair and regeneration in osteoarthritis (OA). OA is a degenerative joint disease characterized by cartilage deterioration and inflammatory changes in the underlying bone. Injectable hydrogels offer a promising approach for controlled drug delivery, providing sustained therapeutic effects and minimizing systemic side effects. The review discusses the pathogenesis of OA, the various types of injectable hydrogels used for intra-articular delivery, and their fabrication strategies. Specifically, physically and chemically crosslinked injectable hydrogels are critically analyzed, emphasizing their capacity to encapsulate and release therapeutic agents. The potential of incorporating growth factors, anti-inflammatory drugs, and cells within these hydrogels is also highlighted. Overall, the review provides a comprehensive guide to the landscape of hydrogel-based therapeutics in OA, offering insights into the latest advancements and their potential in cartilage repair and regeneration.This review focuses on the latest advancements in using injectable hydrogels for targeted drug delivery to promote cartilage repair and regeneration in osteoarthritis (OA). OA is a degenerative joint disease characterized by cartilage deterioration and inflammatory changes in the underlying bone. Injectable hydrogels offer a promising approach for controlled drug delivery, providing sustained therapeutic effects and minimizing systemic side effects. The review discusses the pathogenesis of OA, the various types of injectable hydrogels used for intra-articular delivery, and their fabrication strategies. Specifically, physically and chemically crosslinked injectable hydrogels are critically analyzed, emphasizing their capacity to encapsulate and release therapeutic agents. The potential of incorporating growth factors, anti-inflammatory drugs, and cells within these hydrogels is also highlighted. Overall, the review provides a comprehensive guide to the landscape of hydrogel-based therapeutics in OA, offering insights into the latest advancements and their potential in cartilage repair and regeneration.