The article reviews the similarities and differences between behavioral addictions and substance addictions, emphasizing their common features in natural history, phenomenology, tolerance, comorbidity, genetic contribution, neurobiological mechanisms, and response to treatment. It highlights that behavioral addictions, such as pathological gambling and internet addiction, share many characteristics with substance addictions, including chronic relapsing patterns, subjective craving, intoxication, withdrawal, and overlapping genetic and neurobiological factors. The authors suggest that pathological gambling should be classified as a non-substance or behavioral addiction in the DSM-V, while other behavioral addictions lack sufficient evidence for classification. The article also discusses the potential role of dopamine and serotonin systems in both types of addictions and the effectiveness of treatments for both. However, it concludes that more research is needed to fully understand and classify behavioral addictions.The article reviews the similarities and differences between behavioral addictions and substance addictions, emphasizing their common features in natural history, phenomenology, tolerance, comorbidity, genetic contribution, neurobiological mechanisms, and response to treatment. It highlights that behavioral addictions, such as pathological gambling and internet addiction, share many characteristics with substance addictions, including chronic relapsing patterns, subjective craving, intoxication, withdrawal, and overlapping genetic and neurobiological factors. The authors suggest that pathological gambling should be classified as a non-substance or behavioral addiction in the DSM-V, while other behavioral addictions lack sufficient evidence for classification. The article also discusses the potential role of dopamine and serotonin systems in both types of addictions and the effectiveness of treatments for both. However, it concludes that more research is needed to fully understand and classify behavioral addictions.