Invasive mammalian predators are a significant threat to global biodiversity, contributing to the decline and extinction of numerous species. A global meta-analysis reveals that these predators are implicated in the extinction of 87 bird, 45 mammal, and 10 reptile species, representing 58% of all extinctions in these groups. Cats, rodents, dogs, and pigs are the most damaging predators, with rodents and cats responsible for 44% of extinctions. The impacts are particularly severe on insular environments, where endemic species are most vulnerable. The study highlights the urgent need for management and control of invasive predators on islands to protect phylogenetic diversity and reduce the rate of global biodiversity loss.Invasive mammalian predators are a significant threat to global biodiversity, contributing to the decline and extinction of numerous species. A global meta-analysis reveals that these predators are implicated in the extinction of 87 bird, 45 mammal, and 10 reptile species, representing 58% of all extinctions in these groups. Cats, rodents, dogs, and pigs are the most damaging predators, with rodents and cats responsible for 44% of extinctions. The impacts are particularly severe on insular environments, where endemic species are most vulnerable. The study highlights the urgent need for management and control of invasive predators on islands to protect phylogenetic diversity and reduce the rate of global biodiversity loss.