This review investigates the association between assisted reproduction techniques (ART) and adverse perinatal outcomes. The study analyzed 31 selected studies from 87 full-text articles published between July 2023 and September 2023. The findings indicate that ART pregnancies are associated with a higher risk of congenital and chromosomal defects, as well as an increased incidence of male genital tract defects and heart defects. However, the results regarding pre-term birth (PTB) were contradictory, with some studies showing no significant difference between ART and naturally conceived pregnancies. The review also found that ART-conceived pregnancies had a higher risk of hypospadias and other urological defects, possibly linked to increased exposure to progesterone. Additionally, ART offspring showed increased risks of heart and metabolic defects, including elevated blood pressure and triglyceride levels. While ART is associated with increased risks, the study concludes that these techniques are generally safe regarding perinatal outcomes, and couples should not be discouraged from using them. The review highlights the need for further research to clarify the underlying mechanisms and provide more personalized care for infertile couples.This review investigates the association between assisted reproduction techniques (ART) and adverse perinatal outcomes. The study analyzed 31 selected studies from 87 full-text articles published between July 2023 and September 2023. The findings indicate that ART pregnancies are associated with a higher risk of congenital and chromosomal defects, as well as an increased incidence of male genital tract defects and heart defects. However, the results regarding pre-term birth (PTB) were contradictory, with some studies showing no significant difference between ART and naturally conceived pregnancies. The review also found that ART-conceived pregnancies had a higher risk of hypospadias and other urological defects, possibly linked to increased exposure to progesterone. Additionally, ART offspring showed increased risks of heart and metabolic defects, including elevated blood pressure and triglyceride levels. While ART is associated with increased risks, the study concludes that these techniques are generally safe regarding perinatal outcomes, and couples should not be discouraged from using them. The review highlights the need for further research to clarify the underlying mechanisms and provide more personalized care for infertile couples.