This review examines the association between assisted reproductive techniques (ART) and adverse perinatal outcomes. The study, conducted from July to September 2023, involved a comprehensive search of databases including Pubmed/Medline, Scopus, and Google Scholar. A total of 87 full-text articles were retrieved, and 31 studies were selected for data extraction. The review found that ART pregnancies are associated with a higher risk of congenital and chromosomal defects, as well as male genital tract defects and heart defects. Regarding pre-term birth, the results were contradictory, with some studies reporting an increased risk and others showing no significant difference compared to spontaneous conceptions. The review concludes that while ART is associated with increased risks, it remains safe for perinatal outcomes, and couples should not be discouraged from using these techniques. The findings aim to alert clinicians to specific outcomes and provide more personalized care and counseling to infertile couples and their children.This review examines the association between assisted reproductive techniques (ART) and adverse perinatal outcomes. The study, conducted from July to September 2023, involved a comprehensive search of databases including Pubmed/Medline, Scopus, and Google Scholar. A total of 87 full-text articles were retrieved, and 31 studies were selected for data extraction. The review found that ART pregnancies are associated with a higher risk of congenital and chromosomal defects, as well as male genital tract defects and heart defects. Regarding pre-term birth, the results were contradictory, with some studies reporting an increased risk and others showing no significant difference compared to spontaneous conceptions. The review concludes that while ART is associated with increased risks, it remains safe for perinatal outcomes, and couples should not be discouraged from using these techniques. The findings aim to alert clinicians to specific outcomes and provide more personalized care and counseling to infertile couples and their children.