The paper provides a comprehensive review of the applications of ionic liquids (ILs) in pharmaceutical and biomedical fields. ILs, known for their unique properties such as structural tunability, good solubility, chemical/thermal stability, and biocompatibility, have gained significant attention due to their potential to address various challenges in drug development and delivery. The review covers recent advancements and future prospects in the use of ILs for drug synthesis, analysis, solubilization, and crystal engineering. Additionally, it explores their biomedical applications, including drug carriers, protein stabilization, antimicrobials, and bioactive ionic liquids. The paper highlights how ILs can enhance drug solubility, improve drug delivery efficiency, and overcome issues related to drug stability and bioavailability. It also discusses the advantages of ILs in green chemistry, environmental sustainability, and the development of novel drug formulations. Overall, the review underscores the growing importance of ILs in advancing pharmaceutical and biomedical research.The paper provides a comprehensive review of the applications of ionic liquids (ILs) in pharmaceutical and biomedical fields. ILs, known for their unique properties such as structural tunability, good solubility, chemical/thermal stability, and biocompatibility, have gained significant attention due to their potential to address various challenges in drug development and delivery. The review covers recent advancements and future prospects in the use of ILs for drug synthesis, analysis, solubilization, and crystal engineering. Additionally, it explores their biomedical applications, including drug carriers, protein stabilization, antimicrobials, and bioactive ionic liquids. The paper highlights how ILs can enhance drug solubility, improve drug delivery efficiency, and overcome issues related to drug stability and bioavailability. It also discusses the advantages of ILs in green chemistry, environmental sustainability, and the development of novel drug formulations. Overall, the review underscores the growing importance of ILs in advancing pharmaceutical and biomedical research.