The article reviews the role of iron metabolism, oxidative stress, and ferroptosis in metabolic-dysfunction-associated steatotic liver disease (MASLD). Iron is essential for various cellular functions but can also cause oxidative stress through the Fenton reaction, leading to cell damage. Oxidative stress is a well-established cause of organ damage, particularly in the liver, where it contributes to MASLD. Ferroptosis, an iron-dependent form of regulated cell death, has emerged as a significant factor in the progression of liver disease. The article discusses the mechanisms of iron metabolism, its connection to oxidative stress, and its relevance to MASLD. It highlights the role of iron overload in MASLD and MASH (metabolic-associated steatohepatitis), and explores potential therapeutic targets, such as inhibitors of ferroptosis, for managing these conditions. The article also examines the impact of oxidative stress and ferroptosis on liver fibrosis and hepatocellular carcinoma (HCC), emphasizing their potential as therapeutic targets. Finally, it concludes by discussing the clinical implications and future research directions in understanding and treating MASLD and related liver diseases.The article reviews the role of iron metabolism, oxidative stress, and ferroptosis in metabolic-dysfunction-associated steatotic liver disease (MASLD). Iron is essential for various cellular functions but can also cause oxidative stress through the Fenton reaction, leading to cell damage. Oxidative stress is a well-established cause of organ damage, particularly in the liver, where it contributes to MASLD. Ferroptosis, an iron-dependent form of regulated cell death, has emerged as a significant factor in the progression of liver disease. The article discusses the mechanisms of iron metabolism, its connection to oxidative stress, and its relevance to MASLD. It highlights the role of iron overload in MASLD and MASH (metabolic-associated steatohepatitis), and explores potential therapeutic targets, such as inhibitors of ferroptosis, for managing these conditions. The article also examines the impact of oxidative stress and ferroptosis on liver fibrosis and hepatocellular carcinoma (HCC), emphasizing their potential as therapeutic targets. Finally, it concludes by discussing the clinical implications and future research directions in understanding and treating MASLD and related liver diseases.