Iron deposition is a crucial pathological change observed in Parkinson's disease (PD). This review provides an overview of iron deposition in PD, from both basic research and clinical perspectives. PD patients exhibit abnormalities in various iron metabolism-related proteins, leading to disruptions in iron distribution, transport, storage, and circulation, ultimately resulting in iron deposition. Excess iron can induce oxidative stress and iron-related cell death, and exacerbate mitochondrial dysfunction, contributing to the progression of PD pathology. Magnetic resonance imaging (MRI) studies have indicated that the characteristics of iron deposition in the brains of PD patients vary, and iron deposition correlates with the clinical symptoms of PD. Iron deposition is a promising target for PD treatment, but further research is needed to elucidate the underlying mechanisms and their impacts on PD. The review also discusses the potential role of iron chelation therapy in PD, highlighting the need for more comprehensive understanding of the mechanisms involved.Iron deposition is a crucial pathological change observed in Parkinson's disease (PD). This review provides an overview of iron deposition in PD, from both basic research and clinical perspectives. PD patients exhibit abnormalities in various iron metabolism-related proteins, leading to disruptions in iron distribution, transport, storage, and circulation, ultimately resulting in iron deposition. Excess iron can induce oxidative stress and iron-related cell death, and exacerbate mitochondrial dysfunction, contributing to the progression of PD pathology. Magnetic resonance imaging (MRI) studies have indicated that the characteristics of iron deposition in the brains of PD patients vary, and iron deposition correlates with the clinical symptoms of PD. Iron deposition is a promising target for PD treatment, but further research is needed to elucidate the underlying mechanisms and their impacts on PD. The review also discusses the potential role of iron chelation therapy in PD, highlighting the need for more comprehensive understanding of the mechanisms involved.