This is an Open Access document downloaded from ORCA, Cardiff University's institutional repository: https://orca.cardiff.ac.uk/id/eprint/162634/ This is the author’s version of a work that was submitted to / accepted for publication. Citation for final published version: Leibenluft, Ellen, Allen, Laura, Althof, Robert, Brotman, Melissa, Burke, Jeffrey, Carlson, Gabrielle, Dickstein, Daniel, Dougherty, Lea, Evans, Spencer, Kircanski, Katharina, Klein, Daniel, Malone, Eleanor, Mazefsky, Carla, Nigg, Joel, Perlman, Susan, Pine, Daniel, Krain Roy, Amy, Salum, Giovanni, Shakeshaft, Amy, Silver, Jamilah, Stoddard, Joel, Thapar, Anita, Tseng, Wan-Ling, Vidal-Ribas, Pablo, Wakschlag, Lauren and Stringaris, Argyris 2024. Irritability in youths: A critical integrative review. The American Journal of Psychiatry 181 (4), pp. 275-290. 10.1176/appi.ajp.20230256 Publishers page: https://doi.org/10.1176/appi.ajp.20230256 ## Please note: Changes made as a result of publishing processes such as copy-editing, formatting and page numbers may not be reflected in this version. For the definitive version of this publication, please refer to the published source. You are advised to consult the publisher's version if you wish to cite this paper. This version is being made available in accordance with publisher policies. See http://orca.cf.ac.uk/policies.html for usage policies. Copyright and moral rights for publications made available in ORCA are retained by the copyright holders. # Irritability in Youth: A Critical Integrative Review Ellen Leibenluft, M.D., Laura E. Allen, M.D., Robert R. Althoff, M.D., Ph.D., Melissa A. Brotman, Ph.D., Jeffrey D. Burke, Ph.D., Gabrielle A. Carlson, M.D., Daniel P. Dickstein, M.D., Lea R. Dougherty, Ph.D., Spencer C. Evans, Ph.D., Katharina Kircanski, Ph.D., Daniel N. Klein, Ph.D., Eleanor P. Malone, B.A., Carla A. Mazefsky, Ph.D., Joel Nigg, Ph.D., Susan B. Perlman, Ph.D., Daniel S. Pine, M.D., Amy Krain Roy, Ph.D., Giovanni A. Salum, M.D., Ph.D., Amy Shakeshaft, Ph.D., JamThis is an Open Access document downloaded from ORCA, Cardiff University's institutional repository: https://orca.cardiff.ac.uk/id/eprint/162634/ This is the author’s version of a work that was submitted to / accepted for publication. Citation for final published version: Leibenluft, Ellen, Allen, Laura, Althof, Robert, Brotman, Melissa, Burke, Jeffrey, Carlson, Gabrielle, Dickstein, Daniel, Dougherty, Lea, Evans, Spencer, Kircanski, Katharina, Klein, Daniel, Malone, Eleanor, Mazefsky, Carla, Nigg, Joel, Perlman, Susan, Pine, Daniel, Krain Roy, Amy, Salum, Giovanni, Shakeshaft, Amy, Silver, Jamilah, Stoddard, Joel, Thapar, Anita, Tseng, Wan-Ling, Vidal-Ribas, Pablo, Wakschlag, Lauren and Stringaris, Argyris 2024. Irritability in youths: A critical integrative review. The American Journal of Psychiatry 181 (4), pp. 275-290. 10.1176/appi.ajp.20230256 Publishers page: https://doi.org/10.1176/appi.ajp.20230256 ## Please note: Changes made as a result of publishing processes such as copy-editing, formatting and page numbers may not be reflected in this version. For the definitive version of this publication, please refer to the published source. You are advised to consult the publisher's version if you wish to cite this paper. This version is being made available in accordance with publisher policies. See http://orca.cf.ac.uk/policies.html for usage policies. Copyright and moral rights for publications made available in ORCA are retained by the copyright holders. # Irritability in Youth: A Critical Integrative Review Ellen Leibenluft, M.D., Laura E. Allen, M.D., Robert R. Althoff, M.D., Ph.D., Melissa A. Brotman, Ph.D., Jeffrey D. Burke, Ph.D., Gabrielle A. Carlson, M.D., Daniel P. Dickstein, M.D., Lea R. Dougherty, Ph.D., Spencer C. Evans, Ph.D., Katharina Kircanski, Ph.D., Daniel N. Klein, Ph.D., Eleanor P. Malone, B.A., Carla A. Mazefsky, Ph.D., Joel Nigg, Ph.D., Susan B. Perlman, Ph.D., Daniel S. Pine, M.D., Amy Krain Roy, Ph.D., Giovanni A. Salum, M.D., Ph.D., Amy Shakeshaft, Ph.D., Jam