A systematic review was conducted to assess the prevalence of burnout among medical students worldwide. The review included 64 studies, with sample sizes ranging from 51 to 2682 participants. Burnout was measured using validated tools such as the Maslach Burnout Inventory (MBI) and the Oldenburg Burnout Inventory (OLBI). The prevalence of burnout ranged from 5.6% to 88%, with higher rates observed in female students and during clinical years of medical education. Factors contributing to burnout included thoughts of abandoning medical education, negative life events, lack of support, dissatisfaction, and poor motivation. Protective factors included social and emotional support, counseling services, and relaxation and physical exercise. The review highlights the need for preventive interventions to address burnout in medical students, as it can lead to severe mental health issues. The findings emphasize the importance of developing strategies to improve coping mechanisms and resilience in future medical professionals. The study also notes the heterogeneity in burnout prevalence due to varying assessment tools and cultural contexts. The results suggest that burnout is a significant issue among medical students, requiring targeted interventions to mitigate its impact on mental health.A systematic review was conducted to assess the prevalence of burnout among medical students worldwide. The review included 64 studies, with sample sizes ranging from 51 to 2682 participants. Burnout was measured using validated tools such as the Maslach Burnout Inventory (MBI) and the Oldenburg Burnout Inventory (OLBI). The prevalence of burnout ranged from 5.6% to 88%, with higher rates observed in female students and during clinical years of medical education. Factors contributing to burnout included thoughts of abandoning medical education, negative life events, lack of support, dissatisfaction, and poor motivation. Protective factors included social and emotional support, counseling services, and relaxation and physical exercise. The review highlights the need for preventive interventions to address burnout in medical students, as it can lead to severe mental health issues. The findings emphasize the importance of developing strategies to improve coping mechanisms and resilience in future medical professionals. The study also notes the heterogeneity in burnout prevalence due to varying assessment tools and cultural contexts. The results suggest that burnout is a significant issue among medical students, requiring targeted interventions to mitigate its impact on mental health.