The article explores the global brain activity changes in Major Depressive Disorder (MDD) and proposes a topographic dynamic reorganization model to explain the co-occurrence of various psychopathological symptoms. It reviews recent findings showing topographic reorganization from unimodal to transmodal regions during both rest and task states. Two candidate mechanisms are identified: dynamic shifts from shorter to longer timescales and abnormalities in the excitation-inhibition balance. The authors argue that these topographic shifts relate to various MDD symptoms, including their co-occurrence, and propose a "Topographic Dynamic Reorganization" model that extends the resting state hypothesis of depression. The model suggests that abnormal synchronization in the default-mode network (DMN) and other regions leads to a shift in neural activity from unimodal to transmodal regions, resulting in reduced speed and altered dynamics. This reorganization is linked to psychological symptoms such as impaired perception, cognition, emotion, and self-awareness. The article also discusses the potential diagnostic relevance of global brain activity measures and the therapeutic effects of interventions targeting these changes.The article explores the global brain activity changes in Major Depressive Disorder (MDD) and proposes a topographic dynamic reorganization model to explain the co-occurrence of various psychopathological symptoms. It reviews recent findings showing topographic reorganization from unimodal to transmodal regions during both rest and task states. Two candidate mechanisms are identified: dynamic shifts from shorter to longer timescales and abnormalities in the excitation-inhibition balance. The authors argue that these topographic shifts relate to various MDD symptoms, including their co-occurrence, and propose a "Topographic Dynamic Reorganization" model that extends the resting state hypothesis of depression. The model suggests that abnormal synchronization in the default-mode network (DMN) and other regions leads to a shift in neural activity from unimodal to transmodal regions, resulting in reduced speed and altered dynamics. This reorganization is linked to psychological symptoms such as impaired perception, cognition, emotion, and self-awareness. The article also discusses the potential diagnostic relevance of global brain activity measures and the therapeutic effects of interventions targeting these changes.