The article discusses the concept that the neocortex is fundamentally multisensory, challenging traditional views that sensory processing occurs in separate, unimodal regions. The authors review evidence showing that multisensory integration occurs not only in higher-order association cortices but also in primary sensory areas. They highlight studies in primates and other mammals that demonstrate multisensory influences at various levels of cortical processing. The article emphasizes that real-world perception and behavior rely on the integration of information from multiple sensory modalities, and that this integration is more widespread than previously thought. The authors argue that focusing solely on unimodal processes provides an incomplete understanding of brain function and behavior. They also discuss the implications of these findings for understanding perception, cognition, and the organization of the neocortex. The review includes examples from visual, auditory, and somatosensory systems, as well as the role of subcortical structures in multisensory integration. The conclusion is that the neocortex is organized to efficiently process multisensory information, and that this has significant implications for how we study and understand the brain.The article discusses the concept that the neocortex is fundamentally multisensory, challenging traditional views that sensory processing occurs in separate, unimodal regions. The authors review evidence showing that multisensory integration occurs not only in higher-order association cortices but also in primary sensory areas. They highlight studies in primates and other mammals that demonstrate multisensory influences at various levels of cortical processing. The article emphasizes that real-world perception and behavior rely on the integration of information from multiple sensory modalities, and that this integration is more widespread than previously thought. The authors argue that focusing solely on unimodal processes provides an incomplete understanding of brain function and behavior. They also discuss the implications of these findings for understanding perception, cognition, and the organization of the neocortex. The review includes examples from visual, auditory, and somatosensory systems, as well as the role of subcortical structures in multisensory integration. The conclusion is that the neocortex is organized to efficiently process multisensory information, and that this has significant implications for how we study and understand the brain.