A study published in Nature (2010) reveals the molecular mechanism of jasmonate (JA) perception in plants. The research identifies a complex involving the F-box protein COI1, the JAZ degron, and inositol pentakisphosphate (InsP5) as the true JA receptor. COI1 recognizes the bioactive hormone JA-Ile with high specificity through an open pocket, while the JAZ degron, consisting of a conserved α-helix and a loop region, ensures high-affinity hormone binding. InsP5, a newly identified component, interacts with both COI1 and JAZ, enhancing the receptor's ability to sense JA. Structural analysis shows that COI1 forms a hormone-binding pocket that specifically recognizes JA-Ile, with the JAZ degron trapping the hormone in the pocket. The study also demonstrates that InsP5 potentiates JA perception by COI1-JAZ1, highlighting its role in the signaling process. The findings provide insights into how plants perceive and respond to JA, which is crucial for growth, development, and defense against stress. The research underscores the importance of multi-component signaling hubs in plant hormone signaling.A study published in Nature (2010) reveals the molecular mechanism of jasmonate (JA) perception in plants. The research identifies a complex involving the F-box protein COI1, the JAZ degron, and inositol pentakisphosphate (InsP5) as the true JA receptor. COI1 recognizes the bioactive hormone JA-Ile with high specificity through an open pocket, while the JAZ degron, consisting of a conserved α-helix and a loop region, ensures high-affinity hormone binding. InsP5, a newly identified component, interacts with both COI1 and JAZ, enhancing the receptor's ability to sense JA. Structural analysis shows that COI1 forms a hormone-binding pocket that specifically recognizes JA-Ile, with the JAZ degron trapping the hormone in the pocket. The study also demonstrates that InsP5 potentiates JA perception by COI1-JAZ1, highlighting its role in the signaling process. The findings provide insights into how plants perceive and respond to JA, which is crucial for growth, development, and defense against stress. The research underscores the importance of multi-component signaling hubs in plant hormone signaling.