A study conducted in Kuwait analyzed 166 breast cancer cases to investigate the pathobiological features of tumors. The study found that the average age of patients under 55 years was 40, while those over 55 had an average age of 68 (p < 0.0001). More than half of the cases were in the right breast, and most were surgically treated with total mastectomy and axillary clearance. The majority of tumors had irregular margins, were invasive, and surrounded by adenosis or fibrocystic breast tissue. They had a mitotic index of 10–20 or more than 20, with marked to moderate nuclear pleomorphism. Most tumors were grade II or III, with sizes of 2–5 cm or more than 5 cm, and were stage II or III. In situ tumors were mainly ductal carcinoma in situ (DCIS), with comedo and cribriform as the major subtypes. Invasive tumors included ductal-not otherwise specified, lobular, and tubular/cribriform subtypes. The study found a significant association between Her-2 overexpression, lack of ER expression, and other characteristics. Breast cancer in Kuwait appears more aggressive than in Europe, North America, Australia, and parts of Asia. The study highlights the need for further research into the molecular pathogenesis of breast cancer in Kuwait. The findings suggest that aggressive tumors often lack hormone receptors and overexpress Her-2, leading to poor prognosis and resistance to therapy. The study also found that tumors with fibrocystic surrounding tissue overexpressed Her-2 and were ER negative. The results indicate that breast cancer in Kuwait is more aggressive, with a higher incidence of Her-2 overexpression and ER negativity, which may contribute to higher mortality rates. The study emphasizes the importance of understanding the molecular mechanisms of breast cancer in Kuwait to improve diagnosis and treatment strategies.A study conducted in Kuwait analyzed 166 breast cancer cases to investigate the pathobiological features of tumors. The study found that the average age of patients under 55 years was 40, while those over 55 had an average age of 68 (p < 0.0001). More than half of the cases were in the right breast, and most were surgically treated with total mastectomy and axillary clearance. The majority of tumors had irregular margins, were invasive, and surrounded by adenosis or fibrocystic breast tissue. They had a mitotic index of 10–20 or more than 20, with marked to moderate nuclear pleomorphism. Most tumors were grade II or III, with sizes of 2–5 cm or more than 5 cm, and were stage II or III. In situ tumors were mainly ductal carcinoma in situ (DCIS), with comedo and cribriform as the major subtypes. Invasive tumors included ductal-not otherwise specified, lobular, and tubular/cribriform subtypes. The study found a significant association between Her-2 overexpression, lack of ER expression, and other characteristics. Breast cancer in Kuwait appears more aggressive than in Europe, North America, Australia, and parts of Asia. The study highlights the need for further research into the molecular pathogenesis of breast cancer in Kuwait. The findings suggest that aggressive tumors often lack hormone receptors and overexpress Her-2, leading to poor prognosis and resistance to therapy. The study also found that tumors with fibrocystic surrounding tissue overexpressed Her-2 and were ER negative. The results indicate that breast cancer in Kuwait is more aggressive, with a higher incidence of Her-2 overexpression and ER negativity, which may contribute to higher mortality rates. The study emphasizes the importance of understanding the molecular mechanisms of breast cancer in Kuwait to improve diagnosis and treatment strategies.