The article "Kick-Starting Wound Healing: A Review of Pro-Healing Drugs" by Bethany L. Patenall, Kristyn A. Carter, and Matthew R. Ramsey provides an in-depth review of the current understanding and progress in developing therapeutic interventions for wound healing, particularly for chronic wounds. The authors highlight the four stages of wound healing: hemostasis, inflammation, proliferation/repair, and remodeling. They discuss the challenges in managing chronic wounds, which often fail to progress through these stages due to underlying medical conditions such as diabetes, cardiovascular disease, and venous/arterial insufficiency. The review covers various types of pro-healing drugs and therapies, including natural products, human-derived factors, and pharmaceutical drugs. Natural products like antibiotics, silver dressings, medicinal honey, curcumin, aloe vera, and birch bark extract are explored for their potential to promote wound healing. Human-derived factors such as mesenchymal stem cells, macrophages, collagenase, placental-derived products, and autologous leucocyte/platelet/fibrin patches are also discussed for their therapeutic benefits. Pharmaceutical drugs, including PDGF (Becaplermin), phenytoin, vitamin A/retinoids, hypochlorous acid, pentoxifylline, and metformin, are reviewed for their roles in enhancing wound healing. The authors emphasize the need for more effective treatments to improve the quality of life for individuals with chronic wounds, highlighting the complexity of the wound environment and the challenges in developing precise and effective therapeutic strategies. They conclude by discussing the potential of biomaterials, such as hydrogels, as delivery systems for targeted drug release, and the importance of further research to understand the underlying mechanisms of wound healing to develop more effective treatments.The article "Kick-Starting Wound Healing: A Review of Pro-Healing Drugs" by Bethany L. Patenall, Kristyn A. Carter, and Matthew R. Ramsey provides an in-depth review of the current understanding and progress in developing therapeutic interventions for wound healing, particularly for chronic wounds. The authors highlight the four stages of wound healing: hemostasis, inflammation, proliferation/repair, and remodeling. They discuss the challenges in managing chronic wounds, which often fail to progress through these stages due to underlying medical conditions such as diabetes, cardiovascular disease, and venous/arterial insufficiency. The review covers various types of pro-healing drugs and therapies, including natural products, human-derived factors, and pharmaceutical drugs. Natural products like antibiotics, silver dressings, medicinal honey, curcumin, aloe vera, and birch bark extract are explored for their potential to promote wound healing. Human-derived factors such as mesenchymal stem cells, macrophages, collagenase, placental-derived products, and autologous leucocyte/platelet/fibrin patches are also discussed for their therapeutic benefits. Pharmaceutical drugs, including PDGF (Becaplermin), phenytoin, vitamin A/retinoids, hypochlorous acid, pentoxifylline, and metformin, are reviewed for their roles in enhancing wound healing. The authors emphasize the need for more effective treatments to improve the quality of life for individuals with chronic wounds, highlighting the complexity of the wound environment and the challenges in developing precise and effective therapeutic strategies. They conclude by discussing the potential of biomaterials, such as hydrogels, as delivery systems for targeted drug release, and the importance of further research to understand the underlying mechanisms of wound healing to develop more effective treatments.