The paper by Grimshaw et al. addresses the critical issue of translating research findings into practice and policy, a process known as knowledge translation (KT). The authors highlight the significant gap between evidence and practice, which leads to suboptimal healthcare outcomes and unnecessary costs. They outline five key questions to guide KT activities: what should be transferred, to whom, by whom, how, and with what effect. The discussion emphasizes the importance of systematic reviews as the basic unit of KT, the need to tailor messages for different audiences, and the role of credible messengers. The paper also reviews various KT models and interventions, such as educational materials, meetings, outreach, opinion leaders, audit and feedback, reminders, tailored interventions, and multifaceted interventions. While there is substantial evidence for KT targeting healthcare professionals and patients, the evidence for KT with policymakers and senior managers is weaker, but innovative approaches are being developed and warrant further evaluation. The authors conclude by advocating for an evidence-based approach to KT, emphasizing the need for robust research to inform KT strategies.The paper by Grimshaw et al. addresses the critical issue of translating research findings into practice and policy, a process known as knowledge translation (KT). The authors highlight the significant gap between evidence and practice, which leads to suboptimal healthcare outcomes and unnecessary costs. They outline five key questions to guide KT activities: what should be transferred, to whom, by whom, how, and with what effect. The discussion emphasizes the importance of systematic reviews as the basic unit of KT, the need to tailor messages for different audiences, and the role of credible messengers. The paper also reviews various KT models and interventions, such as educational materials, meetings, outreach, opinion leaders, audit and feedback, reminders, tailored interventions, and multifaceted interventions. While there is substantial evidence for KT targeting healthcare professionals and patients, the evidence for KT with policymakers and senior managers is weaker, but innovative approaches are being developed and warrant further evaluation. The authors conclude by advocating for an evidence-based approach to KT, emphasizing the need for robust research to inform KT strategies.