The Kyoto Global Consensus Report on Helicobacter pylori gastritis aims to develop a global consensus on four key areas: classification of chronic gastritis and duodenitis, clinical distinction of H. pylori-related dyspepsia from functional dyspepsia, appropriate diagnostic assessment, and treatment strategies. The report was developed through a Delphi method involving expert panels and a face-to-face meeting in Kyoto. Key findings include: 1. **Classification of Gastritis and Duodenitis**: A new classification system based on etiology is recommended for the 11th International Statistical Classification of Diseases (ICD-11). This system categorizes gastritis into infectious, drug-induced, and autoimmune types, with H. pylori-induced gastritis as a specific entity. 2. **Dyspepsia and H. pylori**: H. pylori gastritis is identified as the cause of dyspepsia in a subset of patients. Eradication therapy is recommended as the first-line treatment for H. pylori-infected dyspeptic patients, with sustained symptom relief indicating H. pylori-associated dyspepsia. 3. **Diagnosis of Gastritis**: Image-enhanced endoscopy and grading systems like OLGA and OLGIM are recommended for accurate diagnosis and risk stratification of gastric cancer. 4. **Treatment of H. pylori Gastritis**: Eradication therapy is strongly recommended for all H. pylori-positive individuals, especially before the development of atrophic gastritis and intestinal metaplasia, to minimize the risk of severe complications. The report concludes that a global consensus on gastritis has been established, providing a foundation for future research and clinical practice.The Kyoto Global Consensus Report on Helicobacter pylori gastritis aims to develop a global consensus on four key areas: classification of chronic gastritis and duodenitis, clinical distinction of H. pylori-related dyspepsia from functional dyspepsia, appropriate diagnostic assessment, and treatment strategies. The report was developed through a Delphi method involving expert panels and a face-to-face meeting in Kyoto. Key findings include: 1. **Classification of Gastritis and Duodenitis**: A new classification system based on etiology is recommended for the 11th International Statistical Classification of Diseases (ICD-11). This system categorizes gastritis into infectious, drug-induced, and autoimmune types, with H. pylori-induced gastritis as a specific entity. 2. **Dyspepsia and H. pylori**: H. pylori gastritis is identified as the cause of dyspepsia in a subset of patients. Eradication therapy is recommended as the first-line treatment for H. pylori-infected dyspeptic patients, with sustained symptom relief indicating H. pylori-associated dyspepsia. 3. **Diagnosis of Gastritis**: Image-enhanced endoscopy and grading systems like OLGA and OLGIM are recommended for accurate diagnosis and risk stratification of gastric cancer. 4. **Treatment of H. pylori Gastritis**: Eradication therapy is strongly recommended for all H. pylori-positive individuals, especially before the development of atrophic gastritis and intestinal metaplasia, to minimize the risk of severe complications. The report concludes that a global consensus on gastritis has been established, providing a foundation for future research and clinical practice.