Since January 2020, Elsevier has created a COVID-19 resource center, offering free information in English and Mandarin on the novel coronavirus. The center is hosted on Elsevier Connect, the company's public news and information website. Elsevier grants permission to make all its COVID-19-related research available in PubMed Central and other publicly funded repositories, with unrestricted research reuse and analyses, provided that the original source is acknowledged. This permission is granted for as long as the COVID-19 resource center remains active. The article also reviews the LC3 conjugation system in mammalian autophagy, focusing on the crosstalk between Atg12-conjugation and LC3-modification, the modifications of the three Atg8 homologues (LC3, GABARAP, and GATE-16), and the lipidation and delipidation cycles mediated by hAtg4B. It highlights the role of LC3 in autophagy, cell differentiation, microbial infection, cancer, and neuromuscular diseases. The review discusses the functional divergence among the three Atg8 homologues and the potential roles of GABARAP and GATE-16 in autophagy.Since January 2020, Elsevier has created a COVID-19 resource center, offering free information in English and Mandarin on the novel coronavirus. The center is hosted on Elsevier Connect, the company's public news and information website. Elsevier grants permission to make all its COVID-19-related research available in PubMed Central and other publicly funded repositories, with unrestricted research reuse and analyses, provided that the original source is acknowledged. This permission is granted for as long as the COVID-19 resource center remains active. The article also reviews the LC3 conjugation system in mammalian autophagy, focusing on the crosstalk between Atg12-conjugation and LC3-modification, the modifications of the three Atg8 homologues (LC3, GABARAP, and GATE-16), and the lipidation and delipidation cycles mediated by hAtg4B. It highlights the role of LC3 in autophagy, cell differentiation, microbial infection, cancer, and neuromuscular diseases. The review discusses the functional divergence among the three Atg8 homologues and the potential roles of GABARAP and GATE-16 in autophagy.