The article by Lippi and Plebani provides an overview of the laboratory abnormalities commonly observed in patients with COVID-19 infection. The authors highlight the importance of laboratory medicine in the early detection, diagnosis, and management of the disease. They conducted a comprehensive literature review, selecting 11 studies that reported significant laboratory abnormalities in severe COVID-19 cases. The most frequent abnormalities included lymphopenia, increased C-reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), and D-dimer. These abnormalities were also found to be significant predictors of adverse clinical outcomes, such as the need for intensive care unit (ICU) admission and mortality. The article emphasizes the role of procalcitonin and coagulation tests in assessing the severity and prognosis of COVID-19, noting that procalcitonin levels can indicate bacterial superinfection, which may contribute to a worse prognosis. The authors also discuss the limitations of their analysis, including the small sample size and the need for further research.The article by Lippi and Plebani provides an overview of the laboratory abnormalities commonly observed in patients with COVID-19 infection. The authors highlight the importance of laboratory medicine in the early detection, diagnosis, and management of the disease. They conducted a comprehensive literature review, selecting 11 studies that reported significant laboratory abnormalities in severe COVID-19 cases. The most frequent abnormalities included lymphopenia, increased C-reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), and D-dimer. These abnormalities were also found to be significant predictors of adverse clinical outcomes, such as the need for intensive care unit (ICU) admission and mortality. The article emphasizes the role of procalcitonin and coagulation tests in assessing the severity and prognosis of COVID-19, noting that procalcitonin levels can indicate bacterial superinfection, which may contribute to a worse prognosis. The authors also discuss the limitations of their analysis, including the small sample size and the need for further research.