The article "Landscape of Human Organoids: Ideal Model in Clinics and Research" by Xinxin Han et al. provides a comprehensive overview of the current state and future potential of organoid technology. Organoids, three-dimensional cultures derived from stem cells that mimic the architecture and functionality of native organs, have emerged as a revolutionary tool in biomedical research. The authors highlight the exponential growth in organoid research over the past decade, emphasizing the need for a detailed review to bridge the gap in comprehensive understanding. The review covers eight key aspects of organoid technology, including its historical development, technological advancements, and applications in various biomedical fields. It discusses the advantages of organoids over traditional models, such as animal models and two-dimensional cell cultures, in terms of physiological relevance, accuracy, and efficiency. Organoids are particularly useful in drug development, personalized medicine, and disease modeling, offering insights into complex diseases like cancer, neurodegenerative disorders, and genetic conditions. The article also explores the integration of organoids with advanced technologies like synthetic biology and single-cell omics, which enhance their capabilities in drug discovery, disease modeling, and personalized therapy. The authors discuss the potential of organoids in high-throughput drug screening, toxicology, and clinical trials, highlighting their role in improving patient outcomes and reducing costs. Finally, the review emphasizes the future prospects of organoid technology, including its potential to revolutionize personalized medicine, drug discovery, and clinical research. The authors conclude by offering a broad perspective on the current and future applications of organoid technology, aiming to contribute to the evolving trajectory of this dynamic field.The article "Landscape of Human Organoids: Ideal Model in Clinics and Research" by Xinxin Han et al. provides a comprehensive overview of the current state and future potential of organoid technology. Organoids, three-dimensional cultures derived from stem cells that mimic the architecture and functionality of native organs, have emerged as a revolutionary tool in biomedical research. The authors highlight the exponential growth in organoid research over the past decade, emphasizing the need for a detailed review to bridge the gap in comprehensive understanding. The review covers eight key aspects of organoid technology, including its historical development, technological advancements, and applications in various biomedical fields. It discusses the advantages of organoids over traditional models, such as animal models and two-dimensional cell cultures, in terms of physiological relevance, accuracy, and efficiency. Organoids are particularly useful in drug development, personalized medicine, and disease modeling, offering insights into complex diseases like cancer, neurodegenerative disorders, and genetic conditions. The article also explores the integration of organoids with advanced technologies like synthetic biology and single-cell omics, which enhance their capabilities in drug discovery, disease modeling, and personalized therapy. The authors discuss the potential of organoids in high-throughput drug screening, toxicology, and clinical trials, highlighting their role in improving patient outcomes and reducing costs. Finally, the review emphasizes the future prospects of organoid technology, including its potential to revolutionize personalized medicine, drug discovery, and clinical research. The authors conclude by offering a broad perspective on the current and future applications of organoid technology, aiming to contribute to the evolving trajectory of this dynamic field.