This paper reviews recent advances in the early detection, management, and prevention of hepatocellular carcinoma (HCC). Key advancements include the use of advanced imaging techniques such as MRI and contrast-enhanced ultrasound, which have improved the accuracy of HCC detection and diagnosis. Minimally-invasive techniques like thermal and radiofrequency ablation have enhanced tumor destruction, while nanotechnology, immunotherapy, and targeted therapy have shown promise in managing advanced-stage HCC. Artificial intelligence (AI) and machine learning have revolutionized HCC research, aiding in the identification of high-risk patients and predicting outcomes. Lifestyle modifications, such as weight management, alcohol avoidance, and hepatitis B vaccinations, are crucial for preventing HCC development. The paper also highlights the potential of traditional Chinese medicine and herbal medicines in HCC treatment, although further research is needed to establish their efficacy and safety. Overall, these advancements offer hope for improved patient outcomes and reduced healthcare burden.This paper reviews recent advances in the early detection, management, and prevention of hepatocellular carcinoma (HCC). Key advancements include the use of advanced imaging techniques such as MRI and contrast-enhanced ultrasound, which have improved the accuracy of HCC detection and diagnosis. Minimally-invasive techniques like thermal and radiofrequency ablation have enhanced tumor destruction, while nanotechnology, immunotherapy, and targeted therapy have shown promise in managing advanced-stage HCC. Artificial intelligence (AI) and machine learning have revolutionized HCC research, aiding in the identification of high-risk patients and predicting outcomes. Lifestyle modifications, such as weight management, alcohol avoidance, and hepatitis B vaccinations, are crucial for preventing HCC development. The paper also highlights the potential of traditional Chinese medicine and herbal medicines in HCC treatment, although further research is needed to establish their efficacy and safety. Overall, these advancements offer hope for improved patient outcomes and reduced healthcare burden.