Recent advances in hepatocellular carcinoma (HCC) management and prevention through advanced technologies have significantly improved early detection, diagnosis, and treatment options. The use of advanced imaging techniques such as magnetic resonance imaging (MRI), contrast-enhanced ultrasound (CEUS), and image segmentation technology has enhanced the accuracy of HCC detection. Deep learning models and radiomics have also contributed to more accurate diagnosis. AI and machine learning have revolutionized HCC research by enabling the identification of high-risk patients and predicting outcomes. Minimally-invasive techniques like thermal ablation and radiofrequency ablation allow for precise tumor destruction, while nanoparticles, immunotherapy, and targeted therapy show promise in advanced HCC management. Lifestyle modifications, such as weight management, alcohol avoidance, and hepatitis B vaccination, play a critical role in HCC prevention. However, further research is needed to fully understand the potential benefits of nanoparticles, traditional Chinese medicine, and herbal medicines in HCC treatment. The integration of AI and machine learning in HCC diagnosis and management has improved the accuracy and efficiency of biomarker detection and treatment planning. Advanced imaging techniques like multiparametric MRI and CEUS have enhanced the ability to detect and characterize HCC. Liquid biopsy, involving the analysis of circulating tumor cells, cell-free DNA, and exosomes, offers a non-invasive method for early detection and monitoring of HCC. Nanotechnology has shown promise in targeted drug delivery, enhanced imaging, and improved diagnostic accuracy for HCC. However, challenges remain in the standardization, clinical validation, and safety of these technologies. Traditional Chinese medicine and herbal medicines have shown potential in HCC treatment, but their efficacy and safety require further investigation. Prevention strategies, including vaccination against hepatitis B and C, lifestyle modifications, and pharmacological interventions like aspirin and statins, are essential in reducing HCC risk. The gut microbiota also plays a role in HCC development, and modulating it through probiotics and prebiotics may help prevent HCC. Overall, these advancements highlight the importance of continued research and collaboration to improve HCC management and prevention.Recent advances in hepatocellular carcinoma (HCC) management and prevention through advanced technologies have significantly improved early detection, diagnosis, and treatment options. The use of advanced imaging techniques such as magnetic resonance imaging (MRI), contrast-enhanced ultrasound (CEUS), and image segmentation technology has enhanced the accuracy of HCC detection. Deep learning models and radiomics have also contributed to more accurate diagnosis. AI and machine learning have revolutionized HCC research by enabling the identification of high-risk patients and predicting outcomes. Minimally-invasive techniques like thermal ablation and radiofrequency ablation allow for precise tumor destruction, while nanoparticles, immunotherapy, and targeted therapy show promise in advanced HCC management. Lifestyle modifications, such as weight management, alcohol avoidance, and hepatitis B vaccination, play a critical role in HCC prevention. However, further research is needed to fully understand the potential benefits of nanoparticles, traditional Chinese medicine, and herbal medicines in HCC treatment. The integration of AI and machine learning in HCC diagnosis and management has improved the accuracy and efficiency of biomarker detection and treatment planning. Advanced imaging techniques like multiparametric MRI and CEUS have enhanced the ability to detect and characterize HCC. Liquid biopsy, involving the analysis of circulating tumor cells, cell-free DNA, and exosomes, offers a non-invasive method for early detection and monitoring of HCC. Nanotechnology has shown promise in targeted drug delivery, enhanced imaging, and improved diagnostic accuracy for HCC. However, challenges remain in the standardization, clinical validation, and safety of these technologies. Traditional Chinese medicine and herbal medicines have shown potential in HCC treatment, but their efficacy and safety require further investigation. Prevention strategies, including vaccination against hepatitis B and C, lifestyle modifications, and pharmacological interventions like aspirin and statins, are essential in reducing HCC risk. The gut microbiota also plays a role in HCC development, and modulating it through probiotics and prebiotics may help prevent HCC. Overall, these advancements highlight the importance of continued research and collaboration to improve HCC management and prevention.