The article provides a comprehensive overview of the latest developments and trends in electronic skin (e-skin) technology. E-skins, which mimic the sensory capabilities of human skin, are crucial for advancing human-machine interfaces (HMIs) and enhancing various applications such as wearable electronics, health monitoring, robotics, and smart homes. The authors outline fundamental strategies for achieving high-performance sensing capabilities, including strain, pressure, shear, temperature, humidity, and self-healing. They also introduce complex e-skin systems and their current applications, highlighting the potential of multimodal e-skins integrated with the Internet of Things (IoT) and machine learning (ML). The article concludes by discussing future directions and challenges, emphasizing the ongoing advancements and transformative innovations in e-skin technology. Key materials and mechanisms used in e-skin development are detailed, along with specific examples of advanced e-skin systems and their performance metrics. The review aims to inspire further research and exploration in this emerging field.The article provides a comprehensive overview of the latest developments and trends in electronic skin (e-skin) technology. E-skins, which mimic the sensory capabilities of human skin, are crucial for advancing human-machine interfaces (HMIs) and enhancing various applications such as wearable electronics, health monitoring, robotics, and smart homes. The authors outline fundamental strategies for achieving high-performance sensing capabilities, including strain, pressure, shear, temperature, humidity, and self-healing. They also introduce complex e-skin systems and their current applications, highlighting the potential of multimodal e-skins integrated with the Internet of Things (IoT) and machine learning (ML). The article concludes by discussing future directions and challenges, emphasizing the ongoing advancements and transformative innovations in e-skin technology. Key materials and mechanisms used in e-skin development are detailed, along with specific examples of advanced e-skin systems and their performance metrics. The review aims to inspire further research and exploration in this emerging field.