The article "Layer-by-layer designer nanoarchitectonics for physical and chemical communications in functional materials" by Katsuhiro Ariga, Jingwen Song, and Kohsaku Kawakami explores the potential of layer-by-layer assembly in constructing advanced functional systems. Nanoarchitectonics, a post-nanotechnology concept, uses nanunits of atoms, molecules, and nanomaterials to create asymmetric structures and hierarchical organizations, leading to more advanced functional materials through rational physical and chemical communications. The authors highlight the advantages of layer-by-layer assembly, including its ability to form complex structures and its versatility in applications such as material synthesis, structure control, and biochemistry research. The article is structured into several sections, covering advancements in basic methods, physico-chemical aspects and applications, bio-chemical aspects and applications, and biomedical applications. Key examples include the development of materials with controlled thermal communication, electromagnetic interference shielding, flame retardancy, and chiral mirrors. The authors also discuss the use of layer-by-layer assembly in creating functional structures for drug delivery, tissue regeneration, and antimicrobial drug development. The article emphasizes the importance of understanding and controlling the nanoscopic structure to predict and enhance the performance of materials in various applications. Overall, the article underscores the significance of layer-by-layer assembly in nanoarchitectonics, highlighting its potential to develop advanced functional systems that mimic biological functions and address practical challenges in materials science and technology.The article "Layer-by-layer designer nanoarchitectonics for physical and chemical communications in functional materials" by Katsuhiro Ariga, Jingwen Song, and Kohsaku Kawakami explores the potential of layer-by-layer assembly in constructing advanced functional systems. Nanoarchitectonics, a post-nanotechnology concept, uses nanunits of atoms, molecules, and nanomaterials to create asymmetric structures and hierarchical organizations, leading to more advanced functional materials through rational physical and chemical communications. The authors highlight the advantages of layer-by-layer assembly, including its ability to form complex structures and its versatility in applications such as material synthesis, structure control, and biochemistry research. The article is structured into several sections, covering advancements in basic methods, physico-chemical aspects and applications, bio-chemical aspects and applications, and biomedical applications. Key examples include the development of materials with controlled thermal communication, electromagnetic interference shielding, flame retardancy, and chiral mirrors. The authors also discuss the use of layer-by-layer assembly in creating functional structures for drug delivery, tissue regeneration, and antimicrobial drug development. The article emphasizes the importance of understanding and controlling the nanoscopic structure to predict and enhance the performance of materials in various applications. Overall, the article underscores the significance of layer-by-layer assembly in nanoarchitectonics, highlighting its potential to develop advanced functional systems that mimic biological functions and address practical challenges in materials science and technology.