The chapter discusses the toxicity of lead (Pb) in plants, emphasizing its widespread occurrence due to human, agricultural, and industrial activities. Pb is a potent pollutant that accumulates in soils and sediments, affecting plant growth and health. The uptake of Pb by plants is influenced by soil pH, particle size, cation exchange capacity, and root exudates. Excessive Pb exposure causes various toxicity symptoms, including stunted growth, chlorosis, and darkening of root systems. Pb inhibits photosynthesis, disrupts mineral nutrition and water balance, alters hormonal status, and affects membrane structure and permeability. The review explores the morphological, physiological, and biochemical effects of Pb toxicity and the strategies plants use to detoxify and develop tolerance to Pb. Mechanisms of Pb detoxification include sequestration in the vacuole, phytochelatin synthesis, and binding to glutathione and amino acids. Tolerance is associated with restricting Pb to cell walls, synthesizing osmolytes, and activating antioxidant defense systems. Remediation techniques such as phytoremediation and rhizofiltration show potential for cleaning Pb-contaminated soils.The chapter discusses the toxicity of lead (Pb) in plants, emphasizing its widespread occurrence due to human, agricultural, and industrial activities. Pb is a potent pollutant that accumulates in soils and sediments, affecting plant growth and health. The uptake of Pb by plants is influenced by soil pH, particle size, cation exchange capacity, and root exudates. Excessive Pb exposure causes various toxicity symptoms, including stunted growth, chlorosis, and darkening of root systems. Pb inhibits photosynthesis, disrupts mineral nutrition and water balance, alters hormonal status, and affects membrane structure and permeability. The review explores the morphological, physiological, and biochemical effects of Pb toxicity and the strategies plants use to detoxify and develop tolerance to Pb. Mechanisms of Pb detoxification include sequestration in the vacuole, phytochelatin synthesis, and binding to glutathione and amino acids. Tolerance is associated with restricting Pb to cell walls, synthesizing osmolytes, and activating antioxidant defense systems. Remediation techniques such as phytoremediation and rhizofiltration show potential for cleaning Pb-contaminated soils.