2011 December 29; 365(26): 2453–2462. | Jeffrey L. Carson, M.D., Michael L. Terrin, M.D., M.P.H., Helaine Noveck, M.P.H., David W. Sanders, M.D., Bernard R. Chaitman, M.D., George G. Rhoads, M.D., M.P.H., George Nemo, Ph.D., Karen Dragert, R.N., Lauren Beaupre, P.T., Ph.D., Kevin Hildebrand, M.D., William Macaulay, M.D., Courtland Lewis, M.D., Donald Richard Cook, B.M.Sc., M.D., Gwendolyn Dobbin, C.C.R.P., Khwaja J. Zakriya, M.D., Fred S. Apple, Ph.D., Rebecca A. Horney, B.A., Jay Magaziner, Ph.D., M.S.Hyg., and for the FOCUS Investigators
The study aimed to determine whether a higher hemoglobin threshold for blood transfusion in high-risk patients after hip surgery would improve recovery. A randomized trial was conducted involving 2016 patients aged 50 or older with a history or risk factors for cardiovascular disease and a hemoglobin level below 10 g per deciliter post-surgery. Patients were randomly assigned to a liberal (hemoglobin threshold of 10 g per deciliter) or restrictive (hemoglobin <8 g per deciliter or symptoms) transfusion strategy. The primary outcome was death or inability to walk without assistance at 60 days. Results showed that the rates of the primary outcome were similar between the two groups (35.2% vs. 34.7%), with no significant differences in in-hospital acute coronary syndrome or death rates. The study concluded that a liberal transfusion strategy did not reduce mortality or functional impairment in elderly patients at high cardiovascular risk.The study aimed to determine whether a higher hemoglobin threshold for blood transfusion in high-risk patients after hip surgery would improve recovery. A randomized trial was conducted involving 2016 patients aged 50 or older with a history or risk factors for cardiovascular disease and a hemoglobin level below 10 g per deciliter post-surgery. Patients were randomly assigned to a liberal (hemoglobin threshold of 10 g per deciliter) or restrictive (hemoglobin <8 g per deciliter or symptoms) transfusion strategy. The primary outcome was death or inability to walk without assistance at 60 days. Results showed that the rates of the primary outcome were similar between the two groups (35.2% vs. 34.7%), with no significant differences in in-hospital acute coronary syndrome or death rates. The study concluded that a liberal transfusion strategy did not reduce mortality or functional impairment in elderly patients at high cardiovascular risk.