Lipid-based nanoparticles (LNPs) are increasingly used in drug delivery systems to enhance the therapeutic efficacy of bioactive compounds. This review discusses various bioactive compounds, including paclitaxel, curcumin, rhodomyrtone, quercetin, kaempferol, resveratrol, epigallocatechin-3-gallate (EGCG), silymarin, and oridonin, and their delivery using lipid-based nanotechnology. These compounds are often poorly soluble, have low bioavailability, and are unstable, limiting their pharmaceutical applications. However, nanotechnology can improve their physicochemical properties and pharmacokinetic profiles, enabling better drug delivery and therapeutic outcomes. Lipid-based nanoparticles, such as liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), are effective in delivering these compounds due to their ability to enhance stability, control release, and improve bioavailability. The review highlights the use of various lipid types, including natural and synthetic phospholipids, steroids, and other lipids, in the formulation of LNPs. It also discusses the advantages of lipid-based delivery systems, such as improved biocompatibility, reduced toxicity, and enhanced therapeutic efficacy. The review emphasizes the importance of lipid-based nanotechnology in overcoming the limitations of traditional drug delivery systems and improving the clinical applications of bioactive compounds.Lipid-based nanoparticles (LNPs) are increasingly used in drug delivery systems to enhance the therapeutic efficacy of bioactive compounds. This review discusses various bioactive compounds, including paclitaxel, curcumin, rhodomyrtone, quercetin, kaempferol, resveratrol, epigallocatechin-3-gallate (EGCG), silymarin, and oridonin, and their delivery using lipid-based nanotechnology. These compounds are often poorly soluble, have low bioavailability, and are unstable, limiting their pharmaceutical applications. However, nanotechnology can improve their physicochemical properties and pharmacokinetic profiles, enabling better drug delivery and therapeutic outcomes. Lipid-based nanoparticles, such as liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), are effective in delivering these compounds due to their ability to enhance stability, control release, and improve bioavailability. The review highlights the use of various lipid types, including natural and synthetic phospholipids, steroids, and other lipids, in the formulation of LNPs. It also discusses the advantages of lipid-based delivery systems, such as improved biocompatibility, reduced toxicity, and enhanced therapeutic efficacy. The review emphasizes the importance of lipid-based nanotechnology in overcoming the limitations of traditional drug delivery systems and improving the clinical applications of bioactive compounds.