The article "Lipid-based nanoparticles as drug delivery carriers for cancer therapy" by Ibtseam Waheed, Anwar Ali, Huma Tabassum, Narjis Khatoon, Wing-Fu Lai, and Xin Zhou, published in *Frontiers in Oncology*, reviews the use of lipid-based nanoparticles (LBNPs) in cancer therapy. LBNPs, including liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), are effective in delivering both hydrophobic and hydrophilic drugs due to their biocompatibility, biodegradability, and entrapment efficiency. The enhanced permeability and retention (EPR) effect, particularly in passive tumor targeting, is a key advantage of LBNPs. The article discusses the characterization of LBNPs, including morphology, size distribution, surface charge, phase transition temperature, and plasma protein interaction. It also covers the synthesis methods of LBNPs, such as bulk nanoprecipitation, solvent-based emulsification, nonsolvent emulsification, microfluidic approaches, and coacervation technology. The potential of LBNPs in drug delivery is highlighted, with specific examples of encapsulating water-soluble and water-insoluble drugs. The article further explores the applications of LBNPs in treating various cancers, including gastric and esophageal cancer, and pancreatic cancer, emphasizing their ability to enhance drug accumulation and therapeutic efficacy while reducing systemic side effects.The article "Lipid-based nanoparticles as drug delivery carriers for cancer therapy" by Ibtseam Waheed, Anwar Ali, Huma Tabassum, Narjis Khatoon, Wing-Fu Lai, and Xin Zhou, published in *Frontiers in Oncology*, reviews the use of lipid-based nanoparticles (LBNPs) in cancer therapy. LBNPs, including liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), are effective in delivering both hydrophobic and hydrophilic drugs due to their biocompatibility, biodegradability, and entrapment efficiency. The enhanced permeability and retention (EPR) effect, particularly in passive tumor targeting, is a key advantage of LBNPs. The article discusses the characterization of LBNPs, including morphology, size distribution, surface charge, phase transition temperature, and plasma protein interaction. It also covers the synthesis methods of LBNPs, such as bulk nanoprecipitation, solvent-based emulsification, nonsolvent emulsification, microfluidic approaches, and coacervation technology. The potential of LBNPs in drug delivery is highlighted, with specific examples of encapsulating water-soluble and water-insoluble drugs. The article further explores the applications of LBNPs in treating various cancers, including gastric and esophageal cancer, and pancreatic cancer, emphasizing their ability to enhance drug accumulation and therapeutic efficacy while reducing systemic side effects.