The study by Quehenberger et al. (2010) provides a comprehensive lipidomics analysis of human plasma, aiming to define the human plasma lipidome and establish novel analytical methodologies. The research involved a pooled human plasma sample from healthy individuals with a balanced gender and ethnic distribution representative of the US population. Over 500 distinct lipid molecular species were quantitatively assessed, covering six main categories: fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterols, and prenols. The study highlights the complexity and diversity of lipids in human plasma, with sterols being the most abundant on a molar basis, followed by triglycerides, glycerophospholipids, and others. The analysis also revealed the presence of various bioactive lipid mediators, such as eicosanoids, and the occurrence of novel lipid species. The findings underscore the importance of lipidomics in understanding lipid biology and its role in health and disease, suggesting that future blood tests may include a broader range of lipid molecules.The study by Quehenberger et al. (2010) provides a comprehensive lipidomics analysis of human plasma, aiming to define the human plasma lipidome and establish novel analytical methodologies. The research involved a pooled human plasma sample from healthy individuals with a balanced gender and ethnic distribution representative of the US population. Over 500 distinct lipid molecular species were quantitatively assessed, covering six main categories: fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterols, and prenols. The study highlights the complexity and diversity of lipids in human plasma, with sterols being the most abundant on a molar basis, followed by triglycerides, glycerophospholipids, and others. The analysis also revealed the presence of various bioactive lipid mediators, such as eicosanoids, and the occurrence of novel lipid species. The findings underscore the importance of lipidomics in understanding lipid biology and its role in health and disease, suggesting that future blood tests may include a broader range of lipid molecules.